Evidence map›Paper›PMID 33305369›Full record

ArticleJournal of the American Geriatrics Society2021

Association of Non-Steroidal Anti-Inflammatory Drugs with Kidney Health in Ambulatory Older Adults.

Jonathan G Amatruda, Ronit Katz, Carmen A Peralta, Michelle M Estrella, Harini Sarathy, Linda F Fried, Anne B Newman, Chirag R Parikh, Joachim H Ix, Mark J Sarnak and 2 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Jonathan G AmatrudaDivision of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-0118-7909
Ronit KatzKidney Research Institute, University of Washington, Seattle, Washington, USA.
Carmen A PeraltaDivision of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Michelle M EstrellaKidney Health Research Collaborative, San Francisco VA Medical Center & University of California, San Francisco, San Francisco, California, USA.
Harini SarathyDivision of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Linda F FriedUniversity of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.
Anne B NewmanUniversity of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.
Chirag R ParikhDivision of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Joachim H IxDivision of Nephrology-Hypertension, Department of Medicine, University of California, San Diego, California, USA.
Mark J SarnakDivision of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA.
Michael G ShlipakKidney Health Research Collaborative, San Francisco VA Medical Center & University of California, San Francisco, San Francisco, California, USA.
Health ABC Study
San Francisco VA Medical Center · USUniversity of Pittsburgh · USJohns Hopkins University · USSan Francisco General Hospital · USTufts Medical Center · USUniversity of California San Diego · USUniversity of Washington · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The Aging Kidney: Chronic Injury, Impaired Functions and Clinical OutcomesR01AG027002 · NIA · TUFTS MEDICAL CENTER · PI PARIKH, SAMIR M, SARNAK, MARK J · 2005 to 2022
$7.3M
Academic Training Program in NephrologyT32DK007219 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, CHI-YUAN · 1986 to 2022
$7.3M
NSAID Use and Multidimensional Assessment of Kidney HealthF32DK126381 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AMATRUDA, JONATHAN · 2020 to 2021
$153k
NCATS NIH HHS UL1 TR001863NIA NIH HHS 2R01AG027002NIA NIH HHS R01 AG027002NIDDK NIH HHS 5T32DK007219-43NIDDK NIH HHS F32 DK126381NIDDK NIH HHS T32 DK007219
6 · The paper itself

Abstract

BACKGROUND/

objectivesNon-steroidal anti-inflammatory drugs (NSAIDs) can cause kidney injury, especially in older adults. However, previously reported associations between NSAID use and kidney health outcomes are inconsistent and limited by reliance on serum creatinine-based GFR estimates. This analysis investigated the association of NSAID use with kidney damage in older adults using multiple kidney health measures.

designCross-sectional and longitudinal analyses.

settingMulticenter, community-based cohort.

participantsTwo thousand nine hundred and ninty nine older adults in the Health ABC Study. A subcohort (n = 500) was randomly selected for additional biomarker measurements. EXPOSURE: Prescription and over-the-counter NSAID use ascertained by self-report. MEASUREMENTS: Baseline estimated glomerular filtration rate (eGFR) by cystatin C (cysC), urine albumin-to-creatinine ratio (ACR), kidney injury molecule-1 (KIM-1), and interleukin-18 (IL-18) were measured in 2,999 participants; alpha-1 microglobulin (α1m), neutrophil gelatinase-associated lipocalin (NGAL), propeptide type III procollagen (PIIINP), and uromodulin (UMOD) were measured in 500 participants. GFR was estimated three times over 10 years and expressed as percent change per year.

resultsParticipants had a mean age of 74 years, 51% were female, and 41% African-American. No eGFR differences were detected between NSAID users (n = 655) and non-users (n = 2,344) at baseline (72 ml/min/1.73 m

conclusionSelf-reported NSAID use was not associated with kidney dysfunction or injury based on multiple measures, raising the possibility of NSAID use without kidney harm in ambulatory older adults. More research is needed to define safe patterns of NSAID consumption.

Indexed as

AgedAnti-Inflammatory Agents, Non-SteroidalCross-Sectional StudiesFemaleGlomerular Filtration RateHumansKidneyLongitudinal StudiesMaleRenal Insufficiency, ChronicAnti-Inflammatory Agents, Non-Steroidalchronic kidney diseasenephrotoxicityNSAIDpharmacoepidemiology

Identifiers

PMID33305369
PMCPMC8021485
OpenAlexW3112519765

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.