Evidence map›Paper›PMID 33308016›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Role of γ-adducin in actin cytoskeleton rearrangements in podocyte pathophysiology.

Wenjun Gao, Yedan Liu, Letao Fan, Baoying Zheng, Joshua R Jefferson, Shaoxun Wang, Huawei Zhang, Xing Fang, Bond V Nguyen, Tongyu Zhu and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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  8. CD44 mediates shear stress mechanotransduction in an in vitro blood-brain barrier model through small GTPases RhoA and Rac1.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Wenjun GaoDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Yedan LiuDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Letao FanDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0001-5328-8050
Baoying ZhengDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Joshua R JeffersonDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Shaoxun WangDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Huawei ZhangDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Xing FangDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Bond V NguyenDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Tongyu ZhuDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Richard J RomanDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Fan FanDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0003-1463-3610
University of Mississippi Medical Center · USSun Yat-sen University · CN

Funding

Project 003 - Lorena AmaralP20GM121334 · UNIVERSITY OF MISSISSIPPI MED CTR · 2025 to 2025
$2.6M
Adducin, actin cytoskeleton and cognitive impairmentsR01AG057842 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI Jan Michael Williams · 2022 to 2023
$775k
NHLBI NIH HHS R01 HL138685NIA NIH HHS R01 AG057842NIA NIH HHS R21 AG050049NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

We recently reported that the enhanced susceptibility to chronic kidney disease (CKD) in the fawn-hooded hypertensive (FHH) rat is caused, at least in part, by a mutation in γ-adducin (ADD3) that attenuates renal vascular function. The present study explored whether

Indexed as

Actin CytoskeletonAdducinsAnimalsArterial PressureCalmodulin-Binding ProteinsCell AdhesionCell LineCell MovementCytoskeletal ProteinsDisease Models, AnimalDisease ProgressionFocal AdhesionsHypertensionIntegrinsMaleMiceAdd3 protein, mouseAdd3 protein, ratAdducinsCalmodulin-Binding ProteinsCytoskeletal ProteinsIntegrinsMonomeric GTP-Binding Proteinsactin cytoskeletonglomeruluspodocyterenal injuryγ-adducin

Identifiers

PMID33308016
PMCPMC7847051
OpenAlexW3112109914

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.