Evidence map›Paper›PMID 33308172›Full record

ArticleBMC bioinformatics2020

Potential predictors of type-2 diabetes risk: machine learning, synthetic data and wearable health devices.

Paola Stolfi, Ilaria Valentini, Maria Concetta Palumbo, Paolo Tieri, Andrea Grignolio, Filippo Castiglione

Registry-linked trialAbstract read
In one paragraph

Article in BMC bioinformatics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06195566 (Physics Informed Machine Learning-based Prediction and Reversion of Impaired Fasting Glucose Management), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06195566 completednot on this mapstarted 2024, after this paper: background citation

Physics Informed Machine Learning-based Prediction and Reversion of Impaired Fasting Glucose Management

TypeobservationalSponsorJelizaveta SokolovskaRan2024 to 2025Enrolled77ConditionsPrediabetic State, Body Weight, Overweight or Obesity, Life Style, Healthy
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Machine learning for diabetes clinical decision support: a review.Advances in computational intelligence · 2022
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paola StolfiInstitute for Applied Mathematics, National Research Council of Italy, Rome, Italy. p.stolfi@iac.cnr.it.ORCID http://orcid.org/0000-0003-3688-5464
Ilaria ValentiniInstitute of Aerospace Medicine "A. Di Loreto", Rome, Italy.
Maria Concetta PalumboInstitute for Applied Mathematics, National Research Council of Italy, Rome, Italy.
Paolo TieriInstitute for Applied Mathematics, National Research Council of Italy, Rome, Italy.
Andrea GrignolioResearch Ethics and Integrity Interdepartmental Center, National Research Council of Italy, Rome, Italy.
Filippo CastiglioneInstitute for Applied Mathematics, National Research Council of Italy, Rome, Italy.

Funding

Horizon 2020 Research and InnovationProgramme 826121Seventh Framework Programme 600803
6 · The paper itself

Abstract

backgroundThe aim of a recent research project was the investigation of the mechanisms involved in the onset of type 2 diabetes in the absence of familiarity. This has led to the development of a computational model that recapitulates the aetiology of the disease and simulates the immunological and metabolic alterations linked to type-2 diabetes subjected to clinical, physiological, and behavioural features of prototypical human individuals.

resultsWe analysed the time course of 46,170 virtual subjects, experiencing different lifestyle conditions. We then set up a statistical model able to recapitulate the simulated outcomes.

conclusionsThe resulting machine learning model adequately predicts the synthetic dataset and can, therefore, be used as a computationally-cheaper version of the detailed mathematical model, ready to be implemented on mobile devices to allow self-assessment by informed and aware individuals. The computational model used to generate the dataset of this work is available as a web-service at the following address: http://kraken.iac.rm.cnr.it/T2DM .

Indexed as

Machine LearningAdultAgedDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedModels, TheoreticalRiskUser-Computer InterfaceWearable Electronic DevicesComputational modelingEmulatorMachine learningRandom forestSynthetic dataT2D

Identifiers

PMID33308172
PMCPMC7733701

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.