Evidence map›Paper›PMID 33309545›Full record

ArticleArchives of biochemistry and biophysics2021

Phosphoserine inhibits neighboring arginine methylation in the RKS motif of histone H3.

Juan A Leal, Zoila M Estrada-Tobar, Frederick Wade, Aron Judd P Mendiola, Alexander Meza, Mariel Mendoza, Paul S Nerenberg, Cecilia I Zurita-Lopez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Juan A LealDepartment of Chemistry and Biochemistry, California State University, Los Angeles, 5151 State University Drive, Los Angeles, 90033, CA, USA.
Zoila M Estrada-TobarDepartment of Chemistry and Biochemistry, California State University, Los Angeles, 5151 State University Drive, Los Angeles, 90033, CA, USA.
Frederick WadeDepartment of Physics and Astronomy, California State University, Los Angeles, 5151 State University Drive, Los Angeles, 90033, CA, USA.
Aron Judd P MendiolaDepartment of Chemistry and Biochemistry, California State University, Los Angeles, 5151 State University Drive, Los Angeles, 90033, CA, USA.
Alexander MezaDepartment of Chemistry and Biochemistry, California State University, Los Angeles, 5151 State University Drive, Los Angeles, 90033, CA, USA.
Mariel MendozaDepartment of Chemistry and Biochemistry, California State University, Los Angeles, 5151 State University Drive, Los Angeles, 90033, CA, USA.
Paul S NerenbergDepartment of Physics and Astronomy, California State University, Los Angeles, 5151 State University Drive, Los Angeles, 90033, CA, USA; Department of Biological Sciences, California State University, Los Angeles, 5151 State University Drive, Los Angeles, 90033, CA, USA.
Cecilia I Zurita-LopezDepartment of Chemistry and Biochemistry, California State University, Los Angeles, 5151 State University Drive, Los Angeles, 90033, CA, USA. Electronic address: zuritalopez@calstatela.edu.
California State University Los Angeles · US

Funding

Research Initiative for Scientific Enhancement (RISE)R25GM061331 · NIGMS · CALIFORNIA STATE UNIVERSITY LOS ANGELES · PI FOSTER, KRISHNA L · 2000 to 2021
$33.1M
The Crosstalk Between Arginine Methylation and Serine Phosphorylation in Histone H3SC2GM118202 · NIGMS · CALIFORNIA STATE UNIVERSITY LOS ANGELES · PI LOPEZ, CECILIA IRENE ZURITA · 2016 to 2018
$438k
NIGMS NIH HHS R25 GM061331NIGMS NIH HHS SC2 GM118202
6 · The paper itself

Abstract

The effects of phosphorylation of histone H3 at serine 10 have been studied in the context of other posttranslational modifications such as lysine methylation. We set out to investigate the impact of phosphoserine-10 on arginine-8 methylation. We performed methylation reactions using peptides based on histone H3 that contain a phosphorylated serine and compared the extent of arginine methylation with unmodified peptides. Results obtained via fluorography indicate that peptides containing a phosphorylated serine-10 inhibit deposition of methyl groups to arginine-8 residues. To further explore the effects of phosphoserine on neighboring arginine residues, we physically characterized the non-covalent interactions between histone H3 phosphoserine-10 and arginine-8 using

Indexed as

Protein Processing, Post-TranslationalAmino Acid MotifsAmino Acid SequenceAnimalsArginineHistonesHumansMethylationMolecular Dynamics SimulationPhosphoserineStatic ElectricityXenopus laevisArginineHistonesPhosphoserineHistone crosstalkMethylarginineMethylationPhosphorylationPhosphoserinePost translational modification (PTM)PRMTSymmetric arginine dimethylation (SDMA)

Identifiers

PMID33309545
PMCPMC11028399
OpenAlexW3111480674

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.