Evidence map›Paper›PMID 33309737›Full record

ArticleBehavioural brain research2021

Aplnr knockout mice display sex-specific changes in conditioned fear.

Lucas T Laudermilk, Kathryn M Harper, Sheryl S Moy, Scott Runyon, Bin Zhou, Beverly Koller, Rangan Maitra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. The Apelinergic System in Pregnancy.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lucas T LaudermilkCenter for Drug Discovery, RTI International, Research Triangle Park, NC, USA.
Kathryn M HarperDepartment of Psychiatry and Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sheryl S MoyDepartment of Psychiatry and Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Scott RunyonCenter for Drug Discovery, RTI International, Research Triangle Park, NC, USA.
Bin ZhouInstitute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang road, Life Science Research Building A-2112, Shanghai, 200031, China.
Beverly KollerDepartment of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Rangan MaitraCenter for Drug Discovery, RTI International, Research Triangle Park, NC, USA. Electronic address: rmaitra@rti.org.
RTI International · USUniversity of North Carolina at Chapel Hill · USChinese Academy of Sciences · CN

Funding

High-throughput targeted mutagenesis of mouse stem cell linesU01HG004080 · NHGRI · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI DE JONG, PIETER J. · 2006 to 2010
$28.1M
Production of Targeted Null Mutations for 10,000 Genes in C57BL/6 ES CellsU01HG004085 · NHGRI · REGENERON PHARMACEUTICALS, INC. · PI VALENZUELA, DAVID MANUEL · 2006 to 2010
$25.3M
Preclinical CoreU54HD079124 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, YUN · 2013 to 2019
$8.0M
UCD KOMP PROJECT REPOSITORYU42RR024244 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2007 to 2010
$7.9M
APJ receptor agonism for metabolic syndrome R01DK103625 · NIDDK · RESEARCH TRIANGLE INSTITUTE · PI MAITRA, RANGAN · 2017 to 2021
$2.4M
NCRR NIH HHS U42 RR024244NHGRI NIH HHS U01 HG004080NHGRI NIH HHS U01 HG004085NICHD NIH HHS U54 HD079124NIDDK NIH HHS R01 DK103625
6 · The paper itself

Abstract

The G-protein-coupled receptor APLNR and its ligands apelin and ELABELA/TODDLER/apela comprise the apelinergic system, a signaling pathway that is critical during development and physiological homeostasis. Targeted regulation of the receptor has been proposed to treat several important diseases including heart failure, pulmonary arterial hypertension and metabolic syndrome. The apelinergic system is widely expressed within the central nervous system (CNS). However, the role of this system in the CNS has not been completely elucidated. Utilizing an Aplnr knockout mouse model, we report here results from tests of sensory ability, locomotion, reward preference, social preference, learning and memory, and anxiety. We find that knockout of Aplnr leads to significant effects on acoustic startle response and sex-specific effects on conditioned fear responses without significant changes in baseline anxiety. In particular, male Aplnr knockout mice display enhanced context- and cue-dependent fear responses. Our results complement previous reports that exogenous Apelin administration reduced conditioned fear and freezing responses in rodent models, and future studies will explore the therapeutic benefit of APLNR-targeted drugs in rodent models of PTSD.

Indexed as

AnimalsApelin ReceptorsBehavior, AnimalConditioning, ClassicalDisease Models, AnimalFearFemaleMaleMiceMice, Inbred C57BLMice, KnockoutSex FactorsStress Disorders, Post-TraumaticApelin ReceptorsAplnr protein, mouseApelinbehaviorconditioned fearPTSDreceptor

Identifiers

PMID33309737
PMCPMC7927638
OpenAlexW3111238485

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.