Evidence map›Paper›PMID 33311598›Full record

Trial reportScientific reports2020

A multivariable miRNA signature delineates the systemic hemodynamic impact of arteriovenous shunt placement in a pilot study.

Dominic Henn, Masood Abu-Halima, Mustafa Kahraman, Florian Falkner, Katharina S Fischer, Janos A Barrera, Kellen Chen, Geoffrey C Gurtner, Andreas Keller, Ulrich Kneser and 2 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Dominic HennHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, 257 Campus Dr. West, Stanford, CA, 94305, USA. dhenn@stanford.edu.
Masood Abu-HalimaInstitute for Human Genetics, Saarland University, Homburg, Germany.
Mustafa KahramanInstitute for Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.
Florian FalknerBG Trauma Center Ludwigshafen, Heidelberg University, Ludwigshafen, Germany.
Katharina S FischerBG Trauma Center Ludwigshafen, Heidelberg University, Ludwigshafen, Germany.
Janos A BarreraHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, 257 Campus Dr. West, Stanford, CA, 94305, USA.
Kellen ChenHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, 257 Campus Dr. West, Stanford, CA, 94305, USA.
Geoffrey C GurtnerHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, 257 Campus Dr. West, Stanford, CA, 94305, USA.
Andreas KellerInstitute for Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.
Ulrich KneserBG Trauma Center Ludwigshafen, Heidelberg University, Ludwigshafen, Germany.
Eckart MeeseInstitute for Human Genetics, Saarland University, Homburg, Germany.
Volker J SchmidtBG Trauma Center Ludwigshafen, Heidelberg University, Ludwigshafen, Germany.
Saarland University · DEStanford University · USLudwigshafen University of Business and Society · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arteriovenous (AV) fistulas for hemodialysis can lead to cardiac volume loading and increased serum brain natriuretic peptide (BNP) levels. Whether short-term AV loop placement in patients undergoing microsurgery has an impact on cardiac biomarkers and circulating microRNAs (miRNAs), potentially indicating an increased hemodynamic risk, remains elusive. Fifteen patients underwent AV loop placement with delayed free flap anastomosis for microsurgical reconstructions of lower extremity soft-tissue defects. N-terminal pro-BNP (NT-proBNP), copeptin (CT-proAVP), and miRNA expression profiles were determined in the peripheral blood before and after AV loop placement. MiRNA expression in the blood was correlated with miRNA expression from AV loop vascular tissue. Serum NT-proBNP and copeptin levels exceeded the upper reference limit after AV loop placement, with an especially strong NT-proBNP increase in patients with preexistent cardiac diseases. A miRNA signature of 4 up-regulated (miR-3198, miR-3127-5p, miR-1305, miR-1288-3p) and 2 down-regulated miRNAs (miR30a-5p, miR-145-5p) which are related to cardiovascular physiology, showed a significant systemic deregulation in blood and venous tissue after AV loop placement. AV loop placement causes serum elevations of NT-proBNP, copeptin as well as specific circulating miRNAs, indicating a potentially increased hemodynamic risk for patients with cardiovascular comorbidities, if free flap anastomosis is delayed.

Indexed as

Arteriovenous Shunt, SurgicalHemodynamicsRenal DialysisAdultAgedAged, 80 and overCirculating MicroRNAFemaleGlycopeptidesHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsPilot ProjectsCirculating MicroRNAcopeptinsGlycopeptidesNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)

Identifiers

PMID33311598
PMCPMC7733519
OpenAlexW3113144091

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.