SGLT2 inhibitors × kidney outcomes

TrialKidney international2021

Insights from CREDENCE trial indicate an acute drop in estimated glomerular filtration rate during treatment with canagliflozin with implications for clinical practice.

Megumi Oshima et al.PubMed ↗Publisher ↗

  • Canagliflozinlooks good hereHigher drop in eGFR over 10%.Randomised, large.

What the trial testedrandomised · 4,289 people · 2021

Randomised vs placebo

Raised drop in eGFR over 10%

2.6× to 3.5×

canagliflozin vs placebo

Bigger than 9 in 10 on the map

As reported

OR 3.03, 95% CI 2.65–3.47

Who was studied, and how

4,289people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

canagliflozin
placebo

Raised drop in eGFR over 10%

randomised

the abstract, start to end

compared to placebo was significant at 3.03 (95% confidence interval 2.65,

← favours treatmentfavours comparator →
could be chance
Drop in eGFR over 10%canagliflozin vs placebo
OR 3.032.65–3.47
SGLT2 inhibitorsKidney outcomes

SGLT2 inhibitors × kidney outcomeshelps?settled

unlikelylikely
0.890.88 without it
← favours comparatorfavours treatment →
this papermore certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 33316282