Evidence map›Paper›PMID 33317583›Full record

ArticleMolecular brain2020

Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells.

Whitney S McDonald, Kyoko Miyamoto, Richard Rivera, Grace Kennedy, Beatriz S V Almeida, Marcy A Kingsbury, Jerold Chun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Whitney S McDonaldSanford Burnham Prebys Medical Discovery Institute, 10901 N Torrey Pines Rd, La Jolla, CA, 92037, USA.
Kyoko MiyamotoThe Scripps Research Institute, La Jolla, CA, 92037, USA.
Richard RiveraSanford Burnham Prebys Medical Discovery Institute, 10901 N Torrey Pines Rd, La Jolla, CA, 92037, USA.
Grace KennedySanford Burnham Prebys Medical Discovery Institute, 10901 N Torrey Pines Rd, La Jolla, CA, 92037, USA.
Beatriz S V AlmeidaThe Scripps Research Institute, La Jolla, CA, 92037, USA.
Marcy A KingsburyThe Scripps Research Institute, La Jolla, CA, 92037, USA.
Jerold ChunSanford Burnham Prebys Medical Discovery Institute, 10901 N Torrey Pines Rd, La Jolla, CA, 92037, USA. jchun@sbpdiscovery.org.ORCID 0000-0003-3964-0921
Scripps Research Institute · US

Funding

Mechanisms and consequences of CNS aneuploidies altered by fetal ethanol exposureR01AA021402 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI CHUN, JEROLD · 2013 to 2017
$1.9M
NIAAA NIH HHS R01 AA021402
6 · The paper itself

Abstract

The brain is composed of cells having distinct genomic DNA sequences that arise post-zygotically, known as somatic genomic mosaicism (SGM). One form of SGM is aneuploidy-the gain and/or loss of chromosomes-which is associated with mitotic spindle defects. The mitotic spindle orientation determines cleavage plane positioning and, therefore, neural progenitor cell (NPC) fate during cerebral cortical development. Here we report receptor-mediated signaling by lysophosphatidic acid (LPA) as a novel extracellular signal that influences cleavage plane orientation and produces alterations in SGM by inducing aneuploidy during murine cortical neurogenesis. LPA is a bioactive lipid whose actions are mediated by six G protein-coupled receptors, LPA

Indexed as

AneuploidyGenomeSignal TransductionAdherens JunctionsAnimalsCell AdhesionCell DivisionCell PolarityCell ProliferationCells, CulturedCerebral CortexCerebral VentriclesLysophospholipidsMice, Inbred C57BLMice, KnockoutMosaicismlysophosphatidic acidLysophospholipidsReceptors, Lysophosphatidic AcidAdherens junctionsAneuploidyCleavage planeGPCRHydrocephalusLPALysophospholipidNeural progenitor cellsNPCSomatic genomic mosaicism

Identifiers

PMID33317583
PMCPMC7734743
OpenAlexW3111312171

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.