Evidence map›Paper›PMID 33323311›Full record

Observational studyPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]2021

Preoperative ERCP has no impact on islet yield following total pancreatectomy and islet autotransplantation (TPIAT): Results from the Prospective Observational Study of TPIAT (POST) cohort.

Guru Trikudanathan, B Joseph Elmunzer, Yi Yang, Maisam Abu-El-Haija, David Adams, Syed Ahmad, Appakalai N Balamurugan, Gregory J Beilman, Srinath Chinnakotla, Darwin L Conwell and 19 more

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 11 institutions in 1 country.

Guru TrikudanathanUniversity of Minnesota Minneapolis, MN, USA. Electronic address: triku001@umn.edu.
B Joseph ElmunzerMedical University of South Carolina, Charleston, SC, USA.
Yi YangUniversity of Minnesota Minneapolis, MN, USA.
Maisam Abu-El-HaijaCincinnati Children's Hospital, Cincinnati, OH, USA; University of Cincinnati Medical Center, Cincinnati, OH, USA.
David AdamsMedical University of South Carolina, Charleston, SC, USA.
Syed AhmadUniversity of Cincinnati Medical Center, Cincinnati, OH, USA.
Appakalai N BalamuruganCincinnati Children's Hospital, Cincinnati, OH, USA; University of Cincinnati Medical Center, Cincinnati, OH, USA; University of Louisville, Louisville, KY, USA.
Gregory J BeilmanUniversity of Minnesota Minneapolis, MN, USA.
Srinath ChinnakotlaUniversity of Minnesota Minneapolis, MN, USA.
Darwin L ConwellThe Ohio State University Wexner Medical Center, Columbus, OH, USA.
Martin L FreemanUniversity of Minnesota Minneapolis, MN, USA.
Timothy B GardnerDartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Betul HatipogluCleveland Clinic, Cleveland, OH, USA.
James S HodgesUniversity of Minnesota Minneapolis, MN, USA.
Varvara KirchnerUniversity of Minnesota Minneapolis, MN, USA.
Luis F LaraThe Ohio State University Wexner Medical Center, Columbus, OH, USA.
Leslie Long-SimpsonUniversity of Minnesota Minneapolis, MN, USA.
Rebecca MitchellUniversity of Minnesota Minneapolis, MN, USA.
Katherine MorganMedical University of South Carolina, Charleston, SC, USA.
Jaimie D NathanCincinnati Children's Hospital, Cincinnati, OH, USA; University of Cincinnati Medical Center, Cincinnati, OH, USA.
Bashoo NaziruddinBaylor Health, Dallas, TX, USA.
Andrew PosseltUniversity of California San Francisco, San Francisco, CA, USA.
Timothy L PruettUniversity of Minnesota Minneapolis, MN, USA.
Sarah J SchwarzenbergUniversity of Minnesota Minneapolis, MN, USA.
Vikesh K SinghJohn Hopkins Medical Institutions, Baltimore, MD, USA.
Kerrington SmithDartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Martin WijkstromUniversity of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Piotr WitkowskiUniversity of Chicago, Chicago, IL, USA.
Melena D BellinUniversity of Minnesota Minneapolis, MN, USA.
University of Minnesota · USCincinnati Children's Hospital Medical Center · USMedical University of South Carolina · USDartmouth–Hitchcock Medical Center · USThe Ohio State University Wexner Medical Center · USBaylor Scott & White Health · USCleveland Clinic · USJohns Hopkins University · USUniversity of California, San Francisco · USUniversity of Cincinnati · USUniversity of Illinois Chicago · US

Funding

Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Garth R Swanson · 2020 to 2026
$8.8M
Advancing Treatment for Pancreatitis: A Prospective Observational Study of TPIATR01DK109124 · NIDDK · UNIVERSITY OF MINNESOTA · PI BELLIN, MELENA D. · 2016 to 2021
$4.0M
NIDDK NIH HHS P30 DK123704NIDDK NIH HHS R01 DK109124
6 · The paper itself

Abstract

BACKGROUND AND

aimsMany patients undergoing total pancreatectomy with islet autotransplant (TPIAT) for severe, refractory chronic pancreatitis or recurrent acute pancreatitis have a history of endoscopic retrograde cholangiopancreatography (ERCP). Using data from the multicenter POST (Prospective Observational Study of TPIAT) cohort, we aimed to determine clinical characteristics associated with ERCP and the effect of ERCP on islet yield.

methodsUsing data from 230 participants (11 centers), demographics, pancreatitis history, and imaging features were tested for association with ERCP procedures. Logistic and linear regression were used to assess association of islet yield measures with having any pre-operative ERCPs and with the number of ERCPs, adjusting for confounders.

results175 (76%) underwent ERCPs [median number of ERCPs (IQR) 2 (1-4). ERCP was more common in those with obstructed pancreatic duct (p = 0.0009), pancreas divisum (p = 0.0009), prior pancreatic surgery (p = 0.005), and longer disease duration (p = 0.004). A greater number of ERCPs was associated with disease duration (p < 0.0001), obstructed pancreatic duct (p = 0.006), and prior pancreatic surgery (p = 0.006) and increased risk for positive islet culture (p < 0.0001). Mean total IEQ/kg with vs. without prior ERCP were 4145 (95% CI 3621-4669) vs. 3476 (95% CI 2521-4431) respectively (p = 0.23). Adjusting for confounders, islet yield was not significantly associated with prior ERCP, number of ERCPs, biliary or pancreatic sphincterotomy or stent placement.

conclusionsERCP did not appear to adversely impact islet yield. When indicated, ERCP need not be withheld to optimize islet yield but the risk-benefit ratio of ERCP should be considered given its potential harms, including risk for excessive delay in TPIAT.

Indexed as

AdolescentAdultAgedChildCholangiopancreatography, Endoscopic RetrogradeCohort StudiesFemaleHumansIslets of LangerhansIslets of Langerhans TransplantationMaleMiddle AgedPancreatectomyPancreatic DiseasesPancreatitisProspective StudiesChronic pancreatitisERCPRecurrent acute pancreatitisTotal pancreatectomy and islet autotransplantationTPIAT

Identifiers

PMID33323311
PMCPMC7924984
OpenAlexW3109937131

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.