Evidence map›Paper›PMID 33326186›Full record

ArticleActa ophthalmologica2021

Retinal vessel diameters, flicker-induced retinal vasodilation and retinal oxygen saturation in high- and low-risk pregnancy.

Mozhgan Sharifizad, Doreen Schmidl, René M Werkmeister, Harald Zeisler, Reinhard Told, Julia Binder, Lorenz Küssel, Gerhard Garhöfer, Leopold Schmetterer

Open access · hybridAbstract read
In one paragraph

Article in Acta ophthalmologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Retinal oximetry: new insights into ocular and systemic diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Mozhgan SharifizadDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Doreen SchmidlDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0001-5664-7768
René M WerkmeisterCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-5147-5714
Harald ZeislerDepartment of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
Reinhard ToldDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0003-2046-7081
Julia BinderDepartment of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
Lorenz KüsselDepartment of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
Gerhard GarhöferDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0001-5547-5669
Leopold SchmettererDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-7189-1707
Medical University of Vienna · ATNanyang Technological University · SG

Funding

Austrian Science Fund KLIF 529Austrian Science Fund KLIF 721Singapore National Medical Research Council NMRC/CG/C010A/2017_SERI
6 · The paper itself

Abstract

purposeTo compare retinal vascular parameters between high-risk and low-risk pregnant women over time during pregnancy.

methodsIn a longitudinal study, we included pregnant women with normal blood pressure and normal body mass index (BMI, group 1), pregnant women with systemic hypertension and/or overweight (group 2) and age-matched nonpregnant healthy women (group 3). Using the dynamic vessel analyser (DVA) we investigated flicker-induced vasodilation in retinal arteries (FLA) and veins (FLV), central retinal arterial and vein equivalent (CRAE, CRVE), arterio-venous ratio (AVR) and retinal arterial and venous oxygen saturation (SartO

resultsData from 29 women in group 1, 25 women in group 2 and 33 women in group 3 were included for analysis. FLA, FLV, CRAE, CRVE, AVR and SveinO

conclusionsThe present analysis indicates that flicker-induced retinal vasodilation, retinal vessel diameters and retinal oxygen saturation are altered in high-risk pregnant women. Hence, these parameters are candidate biomarkers for pregnancy complications, a hypothesis that deserves further study.

Indexed as

AdultBlood PressureElectroretinographyFemaleHumansHypertensionLongitudinal StudiesOximetryOxygen SaturationPhotic StimulationPregnancyPregnancy Complications, CardiovascularPregnancy TrimestersRetinal VesselsSlit Lamp MicroscopyVasodilationbiomarkersClinical Trial Database Numberflicker stimulationNCT02340442pregnancyretinal oximetryretinal vessels

Identifiers

PMID33326186
PMCPMC8519143
OpenAlexW3112107523

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.