Evidence map›Paper›PMID 33328213›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

The miR-23a∼27a∼24-2 microRNA Cluster Promotes Inflammatory Polarization of Macrophages.

Austin Boucher, Nathan Klopfenstein, William Morgan Hallas, Jennifer Skibbe, Andrew Appert, Seok Hee Jang, Kirthi Pulakanti, Sridhar Rao, Karen D Cowden Dahl, Richard Dahl

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Regulatory RNAs in immunosenescence.Immunity, inflammation and disease · 2024
    Review
  10. Review
  11. Article
  12. Article
  13. MicroRNAs in Macrophages: Regulators of Activation and Function.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Frontiers in immunology · 2022
    Article
  18. Review
  19. Endometriosis and Cancer: Exploring the Role of Macrophages.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Austin BoucherDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.
Nathan KlopfensteinHarper Cancer Research Institute, South Bend, IN 46617.
William Morgan HallasHarper Cancer Research Institute, South Bend, IN 46617.
Jennifer SkibbeHarper Cancer Research Institute, South Bend, IN 46617.ORCID 0000-0002-7220-3769
Andrew AppertDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.
Seok Hee JangDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.
Kirthi PulakantiBlood Research Institute, Versiti, Milwaukee, WI 53226.ORCID 0000-0003-1167-8493
Sridhar RaoBlood Research Institute, Versiti, Milwaukee, WI 53226.ORCID 0000-0003-2688-9541
Karen D Cowden DahlHarper Cancer Research Institute, South Bend, IN 46617.ORCID 0000-0002-9604-3026
Richard DahlDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556; richdahl@iupui.edu.ORCID 0000-0002-6341-5604
University of Notre Dame · USIndiana University · USMedical College of Wisconsin · USVersiti Blood Center of Wisconsin · US

Funding

Cohesin Mutations in Acute Myelogenous LeukemiaR01CA204231 · NCI · VERSITI WISCONSIN, INC. · PI RAO, SRIDHAR · 2017 to 2021
$1.9M
Fine-tuning of Hematopoiesis by the Mirn23a/b MiRNA ClustersR01DK109051 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DAHL, RICHARD E · 2016 to 2018
$847k
NCI NIH HHS R01 CA204231NIDDK NIH HHS R01 DK109051
6 · The paper itself

Abstract

Macrophages are critical for regulating inflammatory responses. Environmental signals polarize macrophages to either a proinflammatory (M1) state or an anti-inflammatory (M2) state. We observed that the microRNA (miRNA) cluster

Indexed as

AnimalsCell DifferentiationCell Line, TumorCytokinesFemaleHumansInflammationMacrophagesMiceMice, Inbred C57BLMice, KnockoutMicroRNAsNeoplasms, ExperimentalOvarian NeoplasmsTh1 CellsTumor-Associated MacrophagesCytokinesMicroRNAsMirn23b microRNA, mouseMirn24 microRNA, mouseMirn27 microRNA, mouse

Identifiers

PMID33328213
PMCPMC7855803
OpenAlexW3110702182

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.