Evidence map›Paper›PMID 33329564›Full record

ReviewFrontiers in immunology2020

Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell Maturation and Function.

Bo Zhu, Lihua Zhu, Lin Xia, Yuyun Xiong, Qing Yin, Ke Rui

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Lipid metabolism in homeostasis and disease.Signal transduction and targeted therapy · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. The role of deubiquitinases in cardiac disease.Expert reviews in molecular medicine · 2024
    Review
  12. Ubiquitin Signaling in the Immune System.Advances in experimental medicine and biology · 2024
    Review
  13. Article
  14. Viperin deficiency promotes dendritic cell activation and function via NF-kappaB activation during Mycobacterium tuberculosis infection.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Bo ZhuDepartment of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Lihua ZhuDepartment of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Lin XiaDepartment of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Yuyun XiongDepartment of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Qing YinDepartment of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Ke RuiDepartment of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Affiliated Hospital of Jiangsu University · CNJiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) are specialized antigen-presenting cells that play a key role in immune homeostasis and the adaptive immune response. DC-induced immune tolerance or activation is strictly dependent on the distinct maturation stages and migration ability of DCs. Ubiquitination is a reversible protein post-translational modification process that has emerged as a crucial mechanism that regulates DC maturation and function. Recent studies have shown that ubiquitin enzymes, including E3 ubiquitin ligases and deubiquitinases (DUBs), are pivotal regulators of DC-mediated immune function and serve as potential targets for DC-based immunotherapy of immune-related disorders (e.g., autoimmune disease, infections, and tumors). In this review, we summarize the recent progress regarding the molecular mechanisms and function of ubiquitination in DC-mediated immune homeostasis and immune response.

Indexed as

AnimalsCell DifferentiationDendritic CellsHumansProtein Processing, Post-TranslationalUbiquitinationDC maturationdendritic cellsimmune responsespost-translational modificationubiquitination

Identifiers

PMID33329564
PMCPMC7717991
OpenAlexW3104650080

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.