Evidence map›Paper›PMID 33330655›Full record

ArticleFrontiers in cardiovascular medicine2020

The Regulatory Role of Histone Modification on Gene Expression in the Early Stage of Myocardial Infarction.

Jinyu Wang, Bowen Lin, Yanping Zhang, Le Ni, Lingjie Hu, Jian Yang, Liang Xu, Dan Shi, Yi-Han Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Histone modifications of circulating nucleosomes are associated with changes in cell-free DNA fragmentation patterns.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Review
  10. Super-enhancers complexes zoom in transcription in cancer.Journal of experimental & clinical cancer research : CR · 2023
    Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jinyu WangDepartment of Physiology, Shanxi Medical University, Taiyuan, China.
Bowen LinDepartment of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Yanping ZhangDepartment of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Le NiDepartment of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Lingjie HuDepartment of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Jian YangDepartment of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Liang XuDepartment of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Dan ShiDepartment of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Yi-Han ChenDepartment of Physiology, Shanxi Medical University, Taiyuan, China.
Shanghai East Hospital · CNRuijin Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction (MI) is a fatal heart disease with high morbidity and mortality. Various studies have demonstrated that a series of relatively specific biological events occur within 24 h of MI. However, the roles of histone modifications in this pathological process are still poorly understood. To investigate the regulation of histone modifications on gene expression in early MI, we performed RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) on myocardial tissues 24 h after the onset of MI. The genome-wide profiles of five histone marks (H3K27ac, H3K9ac, H3K4me3, H3K9me3, and H3K27me3) were explored through ChIP-seq. RNA-seq identified 1,032 differentially expressed genes (DEGs) between the MI and sham groups. ChIP-seq analysis found that 195 upregulated DEGs were modified by change of at least one of the three active histone marks (H3K27ac, H3K9ac, and H3K4me3), and the biological processes and pathways analysis showed that these DEGs were significantly enriched in cardiomyocyte differentiation and development, inflammation, angiogenesis, and metabolism. In the transcriptional regulatory network,

Indexed as

epigenomicshistone modificationsuper-enhancertranscription factorstranscriptome

Identifiers

PMID33330655
PMCPMC7734124
OpenAlexW3109171854

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.