ArticlePloS one2020
Level of sex hormones and their association with acetylsalicylic acid intolerance and nasal polyposis.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Th2 cytokine-induced mucociliary remodeling in chronic rhinosinusitis: implications for antiviral defense and epithelial function.Respiratory research · 2026Article
- Effects of urban PM2.5 on primary sinonasal epithelial cells in individuals with chronic rhinosinusitis.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Biological Sex and Chronic Rhinosinusitis Diagnosis and Biomarkers.JAMA otolaryngology-- head & neck surgery · 2026Article
- The Relationship of Estrogen Changes With Sinonasal Symptoms and Disease in Women: A Scoping Review.The Laryngoscope · 2025Article
- Sex Hormones and the Risk of Nasal Polyps: A Two-Sample Mendelian Randomization Study.World journal of otorhinolaryngology - head and neck surgery · 2025Article
- Sex and gender in rhinosinusitis: a review.Future microbiology · 2025Review
- Impact of sociodemographic status and sex on chronic rhinosinusitis and olfaction in people with cystic fibrosis.International forum of allergy & rhinology · 2024Article
- Gender Differences in Quality-of-Life Outcome in Patients Undergoing Endoscopic Endonasal Skull Base Surgery.Journal of neurological surgery. Part B, Skull base · 2024Article
- The causal relationship between multiple autoimmune diseases and nasal polyps.Frontiers in immunology · 2023Article
- Hormonal Effects on Asthma, Rhinitis, and Eczema.The journal of allergy and clinical immunology. In practice · 2022Review
- Sex Differences in Otolaryngology: Focus on the Emerging Role of Estrogens in Inflammatory and Pro-Resolving Responses.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic rhinosinusitis may be associated with nasal polyposis. Recurrence of disease is often observed and may be due to an intolerance of acetylsalicylic acid. Sex hormones are known to modulate allergic reactions and inflammation. Whether they may be involved in the development and progression of nasal polyposis has not been investigated yet.
aimExamine the relationship between levels of sex hormones and nasal polyposis.
methodsHormonal levels (estradiol, testosterone and progesterone) in patients with nasal polyposis (n = 26) with or without acetylsalicylic acid-intolerance were determined and compared to hormonal levels in patients with septal deviation (n = 35). Cone-beam computed tomography scans were analysed by using scores as defined by Lund and Mackay and by Kennedy.
resultsOur results show a 5 times greater odds (p = 0.01) for developing nasal polyposis in the presence of lowered estradiol plasma levels than in the presence of normal / elevated levels. When analyzing females and males separately, a 6 times greater odds for females to develop nasal polyposis in the presence of lowered estradiol plasma levels was calculated (p = 0.02). Thus, females are more likely to develop nasal polyposis when they have lowered estradiol levels than males. In addition, female patients showed an increased risk for developing ASA intolerance (p = 0.01).
conclusionVariation of sex hormones may be involved in nasal polyposis. Further studies including more patients to validate the presented results are required. SIGNIFICANCE: Retrospective clinical investigation suggesting a correlation between varying sex hormones and nasal polyposis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.