Evidence mapPaperPMID 33335946Full record

ArticleMolecular therapy. Methods & clinical development2021

CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β

Alexander Kondrashov, Nurul A N Mohd Yusof, Alveera Hasan, Joëlle Goulding, Thusharika Kodagoda, Duc M Hoang, Nguyen T N Vo, Tony Melarangi, Nazanin Dolatshad, Julia Gorelik and 3 more

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. The precise magic of CRISPR.FEBS open bio · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Alexander KondrashovDivision of Cancer and Stem Cells, University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2RD, UK.
Nurul A N Mohd YusofDivision of Cancer and Stem Cells, University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2RD, UK.
Alveera HasanNational Heart and Lung Institute, Imperial College, London W12 0NN, UK.
Joëlle GouldingCentre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Midlands, UK.
Thusharika KodagodaNational Heart and Lung Institute, Imperial College, London W12 0NN, UK.
Duc M HoangDivision of Cancer and Stem Cells, University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2RD, UK.
Nguyen T N VoDivision of Cancer and Stem Cells, University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2RD, UK.
Tony MelarangiDivision of Cancer and Stem Cells, University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2RD, UK.
Nazanin DolatshadNational Heart and Lung Institute, Imperial College, London W12 0NN, UK.
Julia GorelikNational Heart and Lung Institute, Imperial College, London W12 0NN, UK.
Stephen J HillCentre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Midlands, UK.
Sian E HardingNational Heart and Lung Institute, Imperial College, London W12 0NN, UK.
Chris DenningDivision of Cancer and Stem Cells, University of Nottingham Biodiscovery Institute, University Park, Nottingham NG7 2RD, UK.
University of Nottingham · GBImperial College London · GB

Funding

British Heart Foundation PG/14/59/31000British Heart Foundation RG/14/1/30588British Heart Foundation RG/17/13/33173Medical Research Council MR/L012618/1Medical Research Council MR/N020081/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C013105/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C013202/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/K000225/1
6 · The paper itself

Abstract

During normal- and patho-physiological situations, the behavior of the beta2-adrenoreceptor (β

Identifiers

PMID33335946
PMCPMC7733025
OpenAlexW3096820993

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.