ReviewMechanisms of ageing and development2021
Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity.
Review in Mechanisms of ageing and development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Impact of nutraceuticals and dietary supplements on mitochondria modifications in healthy aging: a systematic review of randomized controlled trials.Aging clinical and experimental research · 2022Pooled it
- Impact of exercise training on muscle mitochondria modifications in older adults: a systematic review of randomized controlled trials.Aging clinical and experimental research · 2022Pooled it
- The entropic view of aging: from thermodynamics to biology.Life medicine · 2026Article
- Gut Luminal Exosomes in Young and Old Mice: Multi-Omic Characteristics and Regulation of Gut Permeability.Aging cell · 2026Article
- Increasing indices of frailty in aged female mice are associated with impaired skeletal muscle resilience to downhill running stress.GeroScience · 2026Article
- Social Media Use and Psychological and Nutritional Well-Being in Adults Aged 50 Years and Older: A Cross-Sectional Study.Health science reports · 2026Article
- Immunometabolic resistors of aging in long-lived golden spiny mice.Science advances · 2026Article
- Reserpine prolongs lifespan but compromises locomotion and heat-stress resilience in Drosophila melanogaster.npj aging · 2026Article
- Frailty progression: The role of multimorbidity configurations in frailty transitions and predicting mortality risk among older adults.BMC medicine · 2026Article
- Homeodynamic Rejuvenation: an adaptive framework for resetting skin aging.Frontiers in aging · 2026Article
- A novel assessment of self-perceptions of recovery from illness and injury in U.S. Navy service members.Frontiers in rehabilitation sciences · 2026Article
- Physical Resilience After Hip Fracture: Unpacking the Roles of Resistance and Recovery.Journal of the American Geriatrics Society · 2025Article
- Roadmap for alleviating the manifestations of ageing in the cardiovascular system.Nature reviews. Cardiology · 2025Review
- Multimorbidity patterns in older adults from Northern Netherlands: comparing factor analysis and latent class analysis solutions.BMC geriatrics · 2025Article
- Article
- Unravelling Convergent Signaling Mechanisms Underlying the Aging-Disease Nexus Using Computational Language Analysis.Current issues in molecular biology · 2025Article
- High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and accelerates ageing in progeroid DNA repair-deficient mice.npj metabolic health and disease · 2025Article
- Association between psychological resilience and all-cause mortality in the Health and Retirement Study.BMJ mental health · 2024Article
- Glycosylation in aging and neurodegenerative diseases.Acta biochimica et biophysica Sinica · 2024Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Decline in biological resilience (ability to recover) is a key manifestation of aging that contributes to increase in vulnerability to death with age eventually limiting longevity even in people without major chronic diseases. Understanding the mechanisms of this decline is essential for developing efficient anti-aging and pro-longevity interventions. In this paper we discuss: a) mechanisms of the decline in resilience with age, and aging components that contribute to this decline, including depletion of body reserves, imperfect repair mechanisms, and slowdown of physiological processes and responses with age; b) anti-aging interventions that may improve resilience or attenuate its decline; c) biomarkers of resilience available in human and experimental studies; and d) genetic factors that could influence resilience. There are open questions about optimal anti-aging interventions that would oppose the decline in resilience along with extending longevity limits. However, the area develops quickly, and prospects are exciting.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.