ArticleNeurobiology of stress2020
Hormonal contraceptive phases matter: Resting-state functional connectivity of emotion-processing regions under stress.
Article in Neurobiology of stress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Effects of Oral Contraceptive Pills on Brain Networks: A Conceptual Replication and Extension.Human brain mapping · 2025Trial
- Triple network model of brain connectivity changes related to adverse mood effects in an oral contraceptive placebo-controlled trial.Translational psychiatry · 2023Trial
- Hormonal contraception and mental health: a narrative review of screening, monitoring, and patient-centered care for family physicians.Frontiers in psychiatry · 2026Review
- Optimization of deep learning-based denoising for arterial spin labeling: Effects of averaging and training strategies.Magnetic resonance in medicine · 2025Article
- Mental Health Symptoms in Oral Contraceptive Users During Short-Term Hormone Withdrawal.JAMA network open · 2023Article
- Sex Differences in Neural Correlates of Emotion Regulation in Relation to Resting Heart Rate Variability.Brain topography · 2023Article
- Hormone-based models for comparing menstrual cycle and hormonal contraceptive effects on human resting-state functional connectivity.Frontiers in neuroendocrinology · 2022Article
- Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer's disease.Frontiers in aging neuroscience · 2022Review
- Event-Related Potentials in Women on the Pill: Neural Correlates of Positive and Erotic Stimulus Processing in Oral Contraceptive Users.Frontiers in neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Hormonal contraceptives (HCs) affect various processes related to emotion processing, including emotional memory, fear extinction, and the cortisol response to stress. Despite the modulating role of HCs on the stress response in women and variance in synthetic hormone levels across the HC cycle, little is known about the phase-related effects of HCs on the brain's response to stress. We investigated the effect of HC cycle phase on functional connectivity of memory- and emotion-related regions at rest after exposure to a stressor. Twenty HC users completed two sessions of resting-state functional magnetic resonance imaging after exposure to the cold pressor test, one during the hormone-present HC phase (when synthetic hormones are taken) and one during the hormone-absent HC phase (when synthetic hormones are not taken). Women showed higher functional connectivity between left amygdala and ventromedial prefrontal cortex during the hormone-present phase. During the hormone-absent phase, women showed higher coupling between left parahippocampus and right superior lateral occipital cortex. Our results suggest that the synthetic hormones contained in HCs may protect against the negative effects of stress on functional connectivity of emotional processing regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.