ArticleACS omega2020
3D Printed Ti-6Al-4V Implant with a Micro/Nanostructured Surface and Its Cellular Responses.
Article in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- 3D-printed titanium enhances osteoblastic differentiation and extracellular matrix mineralization: insights from in vitro models.Odontology · 2026Article
- 3D-printed customized semi-restrictive elbow prosthesis for severe pseudoarthritis following comminuted fractures of the distal humerus: A case report and review.Experimental and therapeutic medicine · 2026Article
- Probing the Phase Composition and Surface Roughness in the Biological Response of Additively Manufactured Titanium Alloy Bioimplants.ACS omega · 2026Article
- Titanium-Aluminum-Vanadium Surfaces Generated Using Sequential Nanosecond and Femtosecond Laser Etching Provide Osteogenic Nanotopography on Additively Manufactured Implants.Biomimetics (Basel, Switzerland) · 2025Article
- Surface Quality as a Factor Affecting the Functionality of Products Manufactured with Metal and 3D Printing Technologies.Materials (Basel, Switzerland) · 2024Review
- Nanotextured titanium inhibits bacterial activity and supports cell growth on 2D and 3D substrate: A co-culture study.Biomaterials advances · 2024Article
- Biocompatibility and osteoinductive ability of casein phosphopeptide modified polyetheretherketone.Frontiers in bioengineering and biotechnology · 2023Article
- 3D-printed custom implant for the management of "locked" posterior dislocation of the shoulder joint with reverse Hill-Sachs lesion: a case report.Frontiers in bioengineering and biotechnology · 2023Article
- Article
- A Two-Step Approach to Tune the Micro and Nanoscale Morphology of Porous Niobium Oxide to Promote Osteointegration.Materials (Basel, Switzerland) · 2022Article
- Case Report: Three-dimensional printed prosthesis reconstruction for patello-femoral large osteochondral defects in a patient with distal femoral giant cell tumour: A case report.Frontiers in bioengineering and biotechnology · 2022Article
- Surface Modification Techniques to Produce Micro/Nano-scale Topographies on Ti-Based Implant Surfaces for Improved Osseointegration.Frontiers in bioengineering and biotechnology · 2022Review
- Multifunctional Coatings of Titanium Implants Toward Promoting Osseointegration and Preventing Infection: Recent Developments.Frontiers in bioengineering and biotechnology · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three-dimensional (3D) printing technology has been proved to be a powerful tool for the free-form fabrication of titanium (Ti) implants. However, the surface quality of 3D printed Ti implants is not suitable for clinical application directly. Therefore, surface modification of 3D printed Ti implants is required in order to achieve good biocompatibility and osseointegration. In this study, a novel surface modification method of 3D printed Ti-6Al-4V implants has been proposed, which combined acid etching with hydrothermal treatment to construct micro/nanostructures. Polished TC4 sheets (P), electron beam melting Ti sheets (AE), and micro/nanostructured Ti sheets (AMH) were used in this study to evaluate the effects of different surface morphologies on cellular responses. The surface morphology and 3D topography after treatment were detected via scanning electron microscopy and laser scanning microscopy. The results illustrated that a hierarchical structure comprising micro-valleys and nanowires with a surface roughness of 14.388 μm was successfully constructed. Compared with group P samples, the hydrophilicity of group AMH samples significantly increased with a reduced water contact angle from 54.9° to 4.5°. Cell culture experiments indicated that the micro/nanostructures on the material surface could enhance the cell adhesion and proliferation of MC3T3s. The microstructure could enhance bone-to-implant contact, and the nanostructure could directly interact with some cell membrane receptors. Overall, this study proposes a new strategy to construct micro/nanostructures on the surface of 3D printed Ti-6Al-4V implants and may further serve as a potential modification method for better osteogenesis ability.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.