Evidence map›Paper›PMID 33352888›Full record

ReviewViruses2020

The VP1u of Human Parvovirus B19: A Multifunctional Capsid Protein with Biotechnological Applications.

Carlos Ros, Jan Bieri, Remo Leisi

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  14. Review
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  16. Review
  17. Article
  18. Nuclear entry and egress of parvoviruses.Molecular microbiology · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Carlos RosDepartment of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0002-6964-4002
Jan BieriDepartment of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0001-8401-8002
Remo LeisiDepartment of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0001-7019-0098
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The viral protein 1 unique region (VP1u) of human parvovirus B19 (B19V) is a multifunctional capsid protein with essential roles in virus tropism, uptake, and subcellular trafficking. These functions reside on hidden protein domains, which become accessible upon interaction with cell membrane receptors. A receptor-binding domain (RBD) in VP1u is responsible for the specific targeting and uptake of the virus exclusively into cells of the erythroid lineage in the bone marrow. A phospholipase A

Indexed as

BiotechnologyBinding SitesCapsid ProteinsImmunodominant EpitopesNuclear Localization SignalsParvovirus B19, HumanPhospholipases A2Receptors, VirusViral TropismVirionCapsid Proteinscapsid protein VP1, parvovirus B19Immunodominant EpitopesNuclear Localization SignalsPhospholipases A2Receptors, VirusB19Vbiomarkerdrug deliveryerythroid cellsnanocarrierparvovirus B19PLA2receptorvirus entryVP1u

Identifiers

PMID33352888
PMCPMC7765992
OpenAlexW3111132577

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.