Evidence map›Paper›PMID 33353384›Full record

ArticleCanadian journal of psychiatry. Revue canadienne de psychiatrie2021

Cognition and Its Association with Psychosocial and Occupational Functioning during Treatment with Escitalopram in Patients with Major Depressive Disorder: A CAN-BIND-1 Report: La Cognition Et Son Association Avec Le Fonctionnement Psychosocial Et Professionnel Durant Le Traitement Par Escitalopram Chez Des Patients Souffrant De Trouble Dépressif Majeur: Une Étude Can-Bind-1.

Shane J McInerney, Trisha Chakrabarty, Malgorzata Maciukiewicz, Benicio N Frey, Glenda M MacQueen, Roumen V Milev, Arun V Ravindran, Susan Rotzinger, Sidney H Kennedy, Raymond W Lam and 1 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05017311 (Optimized Predictive Treatment In Medications for Unipolar Major Depression), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05017311 phase4recruitingnot on this mapstarted 2023, after this paper: background citation

Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)

TypeinterventionalSponsorNova Scotia Health AuthorityRan2023 to 2029Enrolled400ConditionsMajor Depressive DisorderArmsEscitalopram, Brexpiprazole
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Shane J McInerneyDepartment of Psychiatry, University of Toronto, Ontario, Canada.ORCID 0000-0003-1062-6464
Trisha ChakrabartyDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
Malgorzata MaciukiewiczCentre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada.
Benicio N FreyDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
Glenda M MacQueenDeceased, formerly Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0003-3352-6781
Roumen V MilevDepartment of Psychiatry, Queen's University, Kingston, Ontario, Canada.
Arun V RavindranDepartment of Psychiatry, University of Toronto, Ontario, Canada.ORCID 0000-0002-1655-2753
Susan RotzingerDepartment of Psychiatry, University of Toronto, Ontario, Canada.
Sidney H KennedyDepartment of Psychiatry, University of Toronto, Ontario, Canada.
Raymond W LamDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0001-7142-4669
CAN-BIND Investigator Team
University of Toronto · CAUniversity of British Columbia · CACentre for Addiction and Mental Health · CAMcMaster University · CAQueen's University · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMajor depressive disorder (MDD) is associated with impairments in both cognition and functioning. However, whether cognitive deficits significantly contribute to impaired psychosocial and occupational functioning, independent of other depressive symptoms, is not well established. We examined the relationship between cognitive performance and functioning in depressed patients before and after antidepressant treatment using secondary data from the first Canadian Biomarker Integration Network in Depression-1 study.

methodsCognition was assessed at baseline in unmedicated, depressed participants with MDD (

resultsBaseline global cognitive functioning, after adjusting for depression symptom severity and demographic variables, was associated with the SDS work/study subscale (β = -0.17;

conclusionCognition was associated with occupational functioning at baseline, but changes in cognition were not associated with psychosocial or occupational functional improvements following escitalopram treatment. We recommend the use of more comprehensive functional assessments to determine the impact of cognitive change on functional outcomes in future research.

Indexed as

Major Depressive DisorderCanadaCitalopramCognitionHumansNuclear FamilyCitalopramantidepressant treatmentcognitiondepressionfunctional outcomes

Identifiers

PMID33353384
PMCPMC8504285
OpenAlexW3117581982

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.