ArticleBMC medicine2020
Gestational lipid profile as an early marker of metabolic syndrome in later life: a population-based prospective cohort study.
Article in BMC medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Maternal biological aging from pregnancy through four years postpartum with disrupted recovery by subsequent pregnancy.iScience · 2026Article
- Pre-pregnancy obesity, gestational weight gain, and their relationship with maternal lipid levels at delivery across racial and ethnic populations.American journal of physiology. Heart and circulatory physiology · 2026Article
- Associations of preconception retinal microvasculature with lipid profiles from mid-pregnancy to three months postpartum.NPJ cardiovascular health · 2026Article
- Trimester-specific association of gestational Atherogenic Index of Plasma (AIP) with adverse pregnancy outcomes among women with and without GDM: a cohort study.BMC endocrine disorders · 2026Article
- Maternal Serum Lipid Levels in the Third Trimester and Associated Factors in Vietnam.Obstetrics and gynecology international · 2026Article
- Maternal Lipids in Pregnancy and Later Life Dyslipidemia: The POUCHmoms Longitudinal Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Association between the atherogenic index of plasma and non-alcoholic fatty liver disease in Korean pregnant women: secondary analysis of a prospective cohort study.Frontiers in nutrition · 2025Article
- The association of early pregnancy dyslipidemia with preterm birth in twin pregnancies: a retrospective cohort study.BMC pregnancy and childbirth · 2024Article
- Association between atherogenic index of plasma and gestational diabetes mellitus: a prospective cohort study based on the Korean population.Cardiovascular diabetology · 2024Article
- Dyslipidaemia management in pregnant patients: a 2024 update.European heart journal open · 2024Review
- Behavior reallocations within 24-h movement profiles and change in cardiometabolic biomarkers during pregnancy.Obesity (Silver Spring, Md.) · 2024Article
- Reproductive risk factors across the female lifecourse and later metabolic health.Cell metabolism · 2024Review
- Association between maternal lipid profiles and vitamin D status in second trimester and risk of LGA or SGA: a retrospective study.Frontiers in endocrinology · 2024Article
- Early pregnancy cardio metabolic risk factors and the prevalence of metabolic syndrome 10 years after the first pregnancy.PloS one · 2023Article
- Maternal lipid levels in early pregnancy as a predictor of childhood lipid levels: a prospective cohort study.BMC pregnancy and childbirth · 2022Article
- Dyslipidemia Management in Pregnancy: Why Is It not Covered in the Guidelines?Current atherosclerosis reports · 2022Review
- Comparison of global definitions of metabolic syndrome in early pregnancy among the Rajarata Pregnancy Cohort participants in Sri Lanka.Scientific reports · 2022Article
- Maternal lipid profile during early pregnancy and birth weight: A retrospective study.Frontiers in endocrinology · 2022Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn pregnancy lipid levels increase with gestation resembling an atherogenic lipid profile. Currently it is unclear whether gestational lipid levels are associated with an adverse cardiovascular risk profile later in life. The aim of this study is to assess the association between gestational lipid levels and lipid levels and prevalence of the metabolic syndrome (MS) six years after pregnancy.
methodsIn plasma of 3510 women from the Generation R Study; a prospective population-based cohort, we measured lipid levels (total cholesterol, triglycerides and high-density lipoprotein cholesterol [HDL-c]), and low-density lipoprotein cholesterol (LDL-c), remnant cholesterol and non-HDL-c were calculated in early pregnancy (median 13.2 weeks, 90% range [10.5 to 17.1]) and six years after pregnancy (median 6.5 years, 90% range [6.2 to 7.8]). MS was assessed six years after pregnancy according to the NCEP/ATP3 criteria. We also examined the influence of pregnancy complications on these associations.
resultsGestational lipid levels were positively associated with corresponding lipid levels six years after pregnancy, independent of pregnancy complications. Six years after pregnancy the prevalence of MS was 10.0%; the prevalence was higher for women with a previous placental syndrome (13.5%). Gestational triglycerides and remnant cholesterol in the highest quartile and HDL-c in the lowest quartile were associated with the highest risk for future MS, independent of smoking and body mass index.
conclusionsGestational lipid levels provide an insight in the future cardiovascular risk profile of women in later life. Monitoring and lifestyle intervention could be indicated in women with an unfavorable gestational lipid profile to optimize timely cardiovascular risk prevention.
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