ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2022
Splenic switch-off as a novel marker for adenosine response in nitrogen-13 ammonia PET myocardial perfusion imaging: Cross-validation against CMR using a hybrid PET/MR device.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Diagnosis of multivessel coronary artery disease usingJapanese journal of radiology · 2026Article
- Splenic contraction associated with sudden, transient hypotension and sympathoexcitation in humans.Experimental physiology · 2026Article
- Clinical significance of splenic switch-off in adenosine triphosphateJapanese journal of radiology · 2025Article
- How to assess nonresponsiveness to vasodilator stress.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024Review
- Adenosine-induced splenic switch-off on [EJNMMI research · 2023Article
- Splenic switch-off in regadenosonJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2022: positron emission tomography, computed tomography, and magnetic resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Left ventricular function and volumes from gated [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Combining body mass index with waist circumference to assess coronary microvascular function in patients with non-obstructive coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Assessing splenic switch-off in Adenosine stress CMR for patients with atrial fibrillation: a propensity-matched study.The British journal of radiology · 2022Article
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14 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundNo methodology is available to distinguish truly reduced myocardial flow reserve (MFR) in positron emission tomography myocardial perfusion imaging (PET MPI) from seemingly impaired MFR due to inadequate adenosine response. The adenosine-induced splenic switch-off (SSO) sign has been proposed as a potential marker for adequate adenosine response in cardiac magnetic resonance (CMR). We assessed the feasibility of detecting SSO in nitrogen-13 ammonia PET MPI using SSO in CMR as the standard of reference. METHODS AND
resultsFifty patients underwent simultaneous CMR and PET MPI on a hybrid PET/MR device with co-injection of a gadolinium-based contrast agent and nitrogen-13 ammonia during rest and adenosine-induced stress. In CMR, SSO was assessed visually (positive vs negative SSO) and quantitatively by calculating the ratio of the peak signal intensity of the spleen during stress over rest (SIR). In PET MPI, the splenic signal activity ratio (SAR) was calculated as the maximal standard uptake value of the spleen during stress over rest. The median SIR was significantly lower in patients with positive versus negative SSO in CMR (0.57 [IQR 0.49 to 0.62] vs 0.89 [IQR 0.76 to 0.98]; P < .001). Similarly, median SAR in PET MPI was significantly lower in patients with positive versus negative SSO (0.40 [IQR 0.32 to 0.45] vs 0.80 [IQR 0.47 to 0.98]; P < .001).
conclusionSimilarly to CMR, SSO can be detected in nitrogen-13 ammonia PET MPI. This might help distinguish adenosine non-responders from patients with truly impaired MFR due to microvascular dysfunction or multivessel coronary artery disease.
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