Evidence map›Paper›PMID 33355140›Full record

ArticleScience advances2020

A unique mechanism of inactivation gating of the Kv channel family member Kv7.1 and its modulation by PIP2 and calmodulin.

Maya Lipinsky, William Sam Tobelaim, Asher Peretz, Luba Simhaev, Adva Yeheskel, Daniel Yakubovich, Guy Lebel, Yoav Paas, Joel A Hirsch, Bernard Attali

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Deep Learning-Based Ion Channel Kinetics Analysis for Automated Patch Clamp Recording.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  3. Targeting the ICirculation research · 2024
    Article
  4. Article
  5. Design of Ultrapotent Genetically Encoded Inhibitors of Kv4.2 for Gating Neural Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  6. Review
  7. Modeling the kinetics of heteromeric potassium channels.Frontiers in cellular neuroscience · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Maya LipinskyDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel.ORCID 0000-0001-9010-939X
William Sam TobelaimDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel.ORCID 0000-0003-4218-6694
Asher PeretzDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel.ORCID 0000-0003-4225-7480
Luba SimhaevThe Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv 69978, Israel.
Adva YeheskelThe Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv 69978, Israel.
Daniel YakubovichDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel.
Guy LebelDepartment of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Yoav PaasThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Joel A HirschDepartment of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.ORCID 0000-0001-7544-8668
Bernard AttaliDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel. battali@tauex.tau.ac.il.ORCID 0000-0003-1066-7047
Tel Aviv University · ILBar-Ilan University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inactivation of voltage-gated K

Indexed as

CalmodulinPotassium Channels, Voltage-GatedFamilyPhosphatidylinositol 4,5-DiphosphateCalmodulinPhosphatidylinositol 4,5-DiphosphatePotassium Channels, Voltage-Gated

Identifiers

PMID33355140
PMCPMC11206195
OpenAlexW3113033908

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.