Evidence map›Paper›PMID 33357565›Full record

ArticlePesticide biochemistry and physiology2021

Stop the crop: Insights into the insecticidal mode of action of cinnamodial against mosquitoes.

Megha Kalsi, Anton Walter, Beenhwa Lee, Andrew DeLaat, Renata Rusconi Trigueros, Katharina Happel, Rose Sepesy, Bao Nguyen, Preston K Manwill, Liva Harinantenaina Rakotondraibe and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pesticide biochemistry and physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Role and Modulation of TRPV1 in Mammalian Spermatozoa: An Updated Review.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Megha KalsiDepartment of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA.
Anton WalterDepartment of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA.
Beenhwa LeeDepartment of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA.
Andrew DeLaatDepartment of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA.
Renata Rusconi TriguerosDepartment of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA.
Katharina HappelDepartment of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA.
Rose SepesyDepartment of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA.
Bao NguyenDepartment of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA.
Preston K ManwillDepartments of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, OH 43210, USA; Center for Applied Plant Sciences, The Ohio State University, Columbus, OH 43210, USA.
Liva Harinantenaina RakotondraibeDepartments of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, OH 43210, USA; Center for Applied Plant Sciences, The Ohio State University, Columbus, OH 43210, USA. Electronic address: rakotondraibe.1@osu.edu.
Peter M PiermariniDepartment of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA; Center for Applied Plant Sciences, The Ohio State University, Columbus, OH 43210, USA. Electronic address: piermarini.1@osu.edu.
The Ohio State University · US

Funding

Development of plant-derived, resistance-breaking mosquitocides for controlling vectors of Zika virusR21AI129951 · NIAID · OHIO STATE UNIVERSITY · PI PIERMARINI, PETER M, RAKOTONDRAIBE, LIVA HARINANTENAINA · 2017 to 2018
$426k
NIAID NIH HHS R21 AI129951
6 · The paper itself

Abstract

Cinnamodial (CDIAL) is a drimane sesquiterpene dialdehyde found in the bark of Malagasy medicinal plants (Cinnamosma species; family Canellaceae). We previously demonstrated that CDIAL was insecticidal, antifeedant, and repellent against Aedes aegypti mosquitoes. The goal of the present study was to generate insights into the insecticidal mode of action for CDIAL, which is presently unknown. We evaluated the effects of CDIAL on the contractility of the ventral diverticulum (crop) isolated from adult female Ae. aegypti. The crop is a food storage organ surrounded by visceral muscle that spontaneously contracts in vitro. We found that CDIAL completely inhibited spontaneous contractions of the crop as well as those stimulated by the agonist 5-hydroxytryptamine. Several derivatives of CDIAL with known insecticidal activity also inhibited crop contractions. Morphometric analyses of crops suggested that CDIAL induced a tetanic paralysis that was dependent on extracellular Ca

Indexed as

AedesInsecticidesInsect RepellentsAnimalsBenzaldehydesFemaleMosquito ControlBenzaldehydescinnamodialInsecticidesInsect RepellentsAedes aegyptiCalcium channelsNatural products, octopamineVentral diverticulumVisceral muscle

Identifiers

PMID33357565
PMCPMC7770332
OpenAlexW3100014343

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.