ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2021
A temporally resolved transcriptome for developing "Keller" explants of the Xenopus laevis dorsal marginal zone.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Folic acid prevention of neural tube defects requires retinoic acid produced by ALDH1L1.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dissecting planar and vertical organiser signals in early chick neural development.Development (Cambridge, England) · 2026Article
- PCP and Septins govern the polarized organization of the actin cytoskeleton during convergent extension.Current biology : CB · 2024Article
- Microsurgical Methods to Isolate and Culture the Early Gastrula Dorsal Marginal Zone.Cold Spring Harbor protocols · 2022Article
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7 authors.
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Abstract
backgroundExplanted tissues from vertebrate embryos reliably develop in culture and have provided essential paradigms for understanding embryogenesis, from early embryological investigations of induction, to the extensive study of Xenopus animal caps, to the current studies of mammalian gastruloids. Cultured explants of the Xenopus dorsal marginal zone ("Keller" explants) serve as a central paradigm for studies of convergent extension cell movements, yet we know little about the global patterns of gene expression in these explants.
resultsIn an effort to more thoroughly develop this important model system, we provide here a time-resolved bulk transcriptome for developing Keller explants.
conclusionsThe dataset reported here provides a useful resource for those using Keller explants for studies of morphogenesis and provide genome-scale insights into the temporal patterns of gene expression in an important tissue when explanted and grown in culture.
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Registered trials
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