Evidence map›Paper›PMID 33369253›Full record

Trial reportPhysiological reports2021

Acute effects of leg heat therapy on walking performance and cardiovascular and inflammatory responses to exercise in patients with peripheral artery disease.

Jacob C Monroe, Qifan Song, Michael S Emery, Daniel M Hirai, Raghu L Motaganahalli, Bruno T Roseguini

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jacob C MonroeDepartment of Health and Kinesiology, Purdue University, West Lafayette, IN, USA.
Qifan SongDepartment of Statistics, Purdue University, West Lafayette, IN, USA.
Michael S EmeryDepartment of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA.
Daniel M HiraiDepartment of Health and Kinesiology, Purdue University, West Lafayette, IN, USA.
Raghu L MotaganahalliDivision of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Bruno T RoseguiniDepartment of Health and Kinesiology, Purdue University, West Lafayette, IN, USA.ORCID 0000-0001-7503-5775
Purdue University West Lafayette · USCleveland Clinic · USIndiana University School of Medicine

Funding

American Heart Association-American Stroke Association 16SDH27600003 AHANIA NIH HHS 1R21AG053687-01A1NIA NIH HHS R21 AG053687
6 · The paper itself

Abstract

Lower-extremity peripheral artery disease (PAD) is associated with increased risk of cardiovascular events and impaired exercise tolerance. We have previously reported that leg heat therapy (HT) applied using liquid-circulating trousers perfused with warm water increases leg blood flow and reduces blood pressure (BP) and the circulating levels of endothelin-1 (ET-1) in patients with symptomatic PAD. In this sham-controlled, randomized, crossover study, sixteen patients with symptomatic PAD (age 65 ± 5.7 years and ankle-brachial index: 0.69 ± 0.1) underwent a single 90-min session of HT or a sham treatment prior to a symptom-limited, graded cardiopulmonary exercise test on the treadmill. The primary outcome was the peak walking time (PWT) during the exercise test. Secondary outcomes included the claudication onset time (COT), resting and exercise BP, calf muscle oxygenation, pulmonary oxygen uptake (V̇O

Indexed as

Blood PressureWalkingAgedEndothelin-1FemaleHumansHyperthermia, InducedInterleukin-6MaleMiddle AgedOxygen ConsumptionPeripheral Arterial DiseaseTumor Necrosis Factor-alphaEndothelin-1Interleukin-6Tumor Necrosis Factor-alphablood pressureendothelin-1heat therapyintermittent claudicationperipheral artery disease

Identifiers

PMID33369253
PMCPMC7758979
OpenAlexW3116691266

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.