Evidence map›Paper›PMID 33372065›Full record

ArticleBiology open2021

A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and Notch signaling.

Katherine K Slemmons, Michael D Deel, Yi-Tzu Lin, Kristianne M Oristian, Nina Kuprasertkul, Katia C Genadry, Po-Han Chen, Jen-Tsan Ashley Chi, Corinne M Linardic

Abstract read
In one paragraph

Article in Biology open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. PLA2 driven lipid signaling drives ARMS tumorigenic cell properties.Cell communication and signaling : CCS · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katherine K SlemmonsDepartments of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina.ORCID 0000-0003-3700-5633
Michael D DeelPediatrics, Duke University School of Medicine, Durham, North Carolina.
Yi-Tzu LinPediatrics, Duke University School of Medicine, Durham, North Carolina.
Kristianne M OristianDepartments of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina.
Nina KuprasertkulDuke University, Durham, North Carolina.ORCID 0000-0003-4282-8589
Katia C GenadryPediatrics, Duke University School of Medicine, Durham, North Carolina.
Po-Han ChenMolecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina.
Jen-Tsan Ashley ChiMolecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina.ORCID 0000-0003-3433-903X
Corinne M LinardicDepartments of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina corinne.linardic@duke.edu.ORCID 0000-0002-3257-2885

Funding

Screening for Cys-Reactive Ligands to Target PAX3-FOXO1U54CA231630 · NCI · DUKE UNIVERSITY · PI COUNTER, CHRISTOPHER M, LINARDIC, CORINNE MARY · 2019 to 2023
$6.5M
Center for Molecular &Cellular Studies of Ped DiseaseK12HD043494 · NICHD · DUKE UNIVERSITY · PI REED, ANN M. · 2003 to 2017
$5.2M
NCI NIH HHS U54 CA231630NICHD NIH HHS K12 HD043494
6 · The paper itself

Abstract

The development of three-dimensional cell culture techniques has allowed cancer researchers to study the stemness properties of cancer cells in

Indexed as

Signal TransductionBiomarkersCell Culture TechniquesCell Line, TumorCell ProliferationCell Transformation, NeoplasticGene Expression ProfilingGene Expression Regulation, NeoplasticHumansNeoplastic Stem CellsReceptors, NotchRhabdomyosarcoma, AlveolarBiomarkersReceptors, NotchFusion-positive rhabdomyosarcomaNANOGNOTCHPOU5F1/OCT4SOX2SpheresStemness

Identifiers

PMID33372065
PMCPMC7888706

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.