Evidence map›Paper›PMID 33374471›Full record

Observational studyGenes2020

Causal Relationship between Adiponectin and Diabetic Retinopathy: A Mendelian Randomization Study in an Asian Population.

Yu-Chuen Huang, Ya-Wen Chang, Chun-Wen Cheng, Chia-Ming Wu, Wen-Ling Liao, Fuu-Jen Tsai

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yu-Chuen HuangSchool of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
Ya-Wen ChangGenetic Center, Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
Chun-Wen ChengInstitute of Medicine, Chung Shan Medical University, Taichung 404, Taiwan.
Chia-Ming WuGenetic Center, Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
Wen-Ling LiaoGraduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan.
Fuu-Jen TsaiSchool of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
China Medical University Hospital · TWChina Medical University · TWChung Shan Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adiponectin (APN) is suggested to be a potential biomarker for predicting diabetic retinopathy (DR) risk, but the association between APN and DR has been inconsistent in observational studies. We used a Mendelian randomization (MR) analysis to evaluate if circulating APN levels result in DR. We applied three different genetic risk scores (GRS): GRS

Indexed as

AdiponectinAgedAsian PeopleDiabetes Mellitus, Type 2Diabetic RetinopathyFemaleGenetic PleiotropyGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisMiddle AgedPolymorphism, Single NucleotideRisk AssessmentTaiwanAdiponectinADIPOQ protein, humanadiponectincausal relationshipdiabetic retinopathyMendelian randomization

Identifiers

PMID33374471
PMCPMC7823606
OpenAlexW3117540750

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.