Evidence map›Paper›PMID 33374656›Full record

ReviewInternational journal of molecular sciences2020

Role of microRNAs in Pressure Ulcer Immune Response, Pathogenesis, and Treatment.

Stephen M Niemiec, Amanda E Louiselle, Kenneth W Liechty, Carlos Zgheib

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

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  15. Breakthrough Technologies in Diagnosis and Therapy of Chronic Wounds.ACS pharmacology & translational science · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Stephen M NiemiecLaboratory for Fetal and Regenerative Biology, Department of Surgery, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0001-7137-0314
Amanda E LouiselleLaboratory for Fetal and Regenerative Biology, Department of Surgery, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.
Kenneth W LiechtyLaboratory for Fetal and Regenerative Biology, Department of Surgery, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.
Carlos ZgheibLaboratory for Fetal and Regenerative Biology, Department of Surgery, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.
Children's Hospital Colorado · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pressure ulcers are preventable, yet highly prevalent, chronic wounds that have significant patient morbidity and high healthcare costs. Like other chronic wounds, they are characterized by impaired wound healing due to dysregulated immune processes. This review will highlight key biochemical pathways in the pathogenesis of pressure injury and how this signaling leads to impaired wound healing. This review is the first to comprehensively describe the current literature on microRNA (miRNA, miR) regulation of pressure ulcer pathophysiology.

Indexed as

Gene Expression RegulationImmunityAnimalsApoptosisDisease ManagementDisease SusceptibilityExtracellular MatrixGene Regulatory NetworksHumansMicroRNAsOxidative StressPressure UlcerReperfusion InjuryRNA InterferenceSignal TransductionWound HealingMicroRNAschronic woundmicroRNA (miRNA, miR)pressure ulcer

Identifiers

PMID33374656
PMCPMC7793489
OpenAlexW3117501693

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.