Evidence map›Paper›PMID 33374840›Full record

ArticleViruses2020

Biochemical and Biophysical Characterization of the dsDNA Packaging Motor from the

Emilio Reyes-Aldrete, Erik A Dill, Cecile Bussetta, Michal R Szymanski, Geoffrey Diemer, Priyank Maindola, Mark A White, Wlodzimierz M Bujalowski, Kyung H Choi, Marc C Morais

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Viral Genomic DNA Packaging Machinery.Sub-cellular biochemistry · 2024
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Emilio Reyes-AldreteDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Erik A DillDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Cecile BussettaDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Michal R SzymanskiDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Geoffrey DiemerDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Priyank MaindolaDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Mark A WhiteDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.ORCID 0000-0003-1057-4203
Wlodzimierz M BujalowskiDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Kyung H ChoiDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Marc C MoraisDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
The University of Texas Medical Branch at Galveston · US

Funding

HOUSTON AREA MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008280 · NIGMS · RICE UNIVERSITY · PI WENSEL, THEODORE G · 1988 to 2023
$8.0M
MECHANISM OF RNA SYNTHESIS BY DENGUE VIRUS NS5R01AI087856 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Kyung H Choi · 2011 to 2026
$5.5M
The DNA Packaging Motor of Bacteriophage phi29R01GM122979 · NIGMS · UNIVERSITY OF MINNESOTA · PI JARDINE, PAUL JAMES, MORAIS, MARC · 2017 to 2024
$4.1M
Structure and Function of Essential Nucleoprotein ComplexesAlong a Viral Genome Packaging PathwayR01GM127365 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Carlos Enrique Catalano, Marc Morais · 2018 to 2026
$3.5M
NIAID NIH HHS R01 AI087856NIGMS NIH HHS GM122979NIGMS NIH HHS GM127365NIGMS NIH HHS R01 GM122979NIGMS NIH HHS T32 GM008280NIGMS NIH HHS T32GM008280
6 · The paper itself

Abstract

Double-stranded DNA viruses package their genomes into pre-assembled protein procapsids. This process is driven by macromolecular motors that transiently assemble at a unique vertex of the procapsid and utilize homomeric ring ATPases to couple genome encapsidation to ATP hydrolysis. Here, we describe the biochemical and biophysical characterization of the packaging ATPase from

Indexed as

Chemical PhenomenaDNA PackagingDNA, ViralAdenosine TriphosphatasesBacteriophagesCloning, MolecularGene ExpressionLactococcus lactisModels, MolecularRecombinant ProteinsSpectrum AnalysisStructure-Activity RelationshipStruviteViral ProteinsVirionVirus AssemblyAdenosine TriphosphatasesDNA, ViralRecombinant ProteinsStruviteViral Proteinsasccphi28ASCE superfamilyATPasebacteriophagedsDNA virusencapsidation proteingenome packagingmolecular motorphage terminasephi29P-loop ATPase

Identifiers

PMID33374840
PMCPMC7823558
OpenAlexW3117564563

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.