Evidence map›Paper›PMID 33375042›Full record

ReviewNutrients2020

Influence of Mediterranean Diet on Human Gut Microbiota.

Giuseppe Merra, Annalisa Noce, Giulia Marrone, Marco Cintoni, Maria Grazia Tarsitano, Annunziata Capacci, Antonino De Lorenzo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 264 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
264citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

264 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  17. The Gut-Heart Axis: A Microbiome-Centered Perspective on Heart Failure.International journal of molecular sciences · 2026
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204 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giuseppe MerraSection of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy.
Annalisa NoceUOC of Internal Medicine, Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0003-1310-3730
Giulia MarroneUOC of Internal Medicine, Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0002-5854-2086
Marco CintoniSection of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0002-9610-0748
Maria Grazia TarsitanoDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Margherita 324, 00100 Rome, Italy.
Annunziata CapacciDepartment of Gastroenterological, Endocrine-Metabolic and Nephro-Urological Sciences, "Agostino Gemelli" General Hospital Foundation-IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.
Antonino De LorenzoSection of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0001-6524-4493

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota changes correlate with health status. Literature data on gut microbiota show that all dietary changes can induce the alteration of gut microbiota composition. Mediterranean diet (MD) is associated with a reduction of all-cause mortality and in this review, we analyzed its interactions with human microbiota. In particular, we explored the modulation of the human microbiota, in response to MD adherence, focusing the attention on polyphenols, polyunsaturated fatty acids (PUFA) ω-3 and fiber. Evidences suggest that MD is able to modulate the gut microbiota, increasing its diversity. In fact, a Mediterranean-type dietary pattern is associated with specific gut microbiota characteristics. The available evidence, suggests that gut microbiota of subjects that follow a MD is significantly different from subjects that follow a Western diet model. In fact, the latter show an increased gut permeability, which is responsible for metabolic endotoxemia. For this reason, we can speculate that the gut microbiota of the subjects following a MD is able to prevent the onset of chronic non-communicable degenerative diseases, such as cardiovascular diseases and some types of cancer. However, in order to understand these correlations with dietary patterns, controlled intervention studies on the gut microbiota composition and activity are needed.

Indexed as

Diet, MediterraneanCardiovascular DiseasesDatabases, FactualDietDietary FiberFatty Acids, Omega-3Fatty Acids, UnsaturatedGastrointestinal MicrobiomeHumansOlive OilPolyphenolsDietary FiberFatty Acids, Omega-3Fatty Acids, UnsaturatedOlive OilPolyphenolsfibergut microbiotaMediterranean dietpolyphenolsω-3 PUFA

Identifiers

PMID33375042
PMCPMC7822000

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.