Evidence map›Paper›PMID 33375174›Full record

Trial reportBiomolecules2020

The Impacts of Fish Oil and/or Probiotic Intervention on Low-Grade Inflammation, IGFBP-1 and MMP-8 in Pregnancy: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial.

Noora Houttu, Kati Mokkala, Ella Koivuniemi, Outi Pellonperä, Juuso Juhila, Timo Sorsa, Kirsi Laitinen

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Noora HouttuInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, 20520 Turku, Finland.ORCID 0000-0002-1350-2187
Kati MokkalaInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, 20520 Turku, Finland.ORCID 0000-0002-0354-5546
Ella KoivuniemiInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, 20520 Turku, Finland.ORCID 0000-0002-5751-3064
Outi PellonperäDepartment of Obstetrics and Gynecology, University of Turku and Turku University Hospital, 20520 Turku, Finland.ORCID 0000-0001-9272-2278
Juuso JuhilaActim Oy, 02180 Espoo, Finland.
Timo SorsaDepartment of Oral and Maxillofacial Disease, University of Helsinki and Helsinki University Hospital, 00014 Helsinki, Finland.
Kirsi LaitinenInstitute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, 20520 Turku, Finland.ORCID 0000-0001-5245-8118
University of Turku · FIUniversity of Helsinki · FI

Funding

Academy of FInland #258606Business Finland #3486/31/2015Huch-TYH 2016252, 2017252, 2018229, Y10114SLO17, Y10114SLO18Jenny and Antti Wihuri Foundation -State research funding for university-level health research of the Turku University Hospital Expert Responsibility Area -the Diabetes Research Foundation -the Juho Vainio Foundation -Turku University Foundation -
6 · The paper itself

Abstract

backgroundWe investigated the impact of fish oil and/or probiotics on serum and vaginal inflammatory and metabolic proteins and their relation to the onset of gestational diabetes mellitus (GDM).

methodsOverweight/obese pregnant women received fish oil + placebo, probiotics + placebo, fish oil + probiotics or placebo + placebo from early pregnancy until six months postpartum (fish oil: 1.9 g docosahexaenoic acid and 0.22 g eicosapentaenoic acid; probiotics:

resultsThe intervention had no impact on the change in proteins during pregnancy. Nevertheless, s-MMP-8 decreased and s-IGFBP-1 increased more in obese than in overweight women in the fish oil + probiotics group, while a decrease in s-MMP-8 was seen in obese women and an increase was seen in overweight women in the probiotics + placebo group. The late pregnancy s-phIGFBP-1 was higher in women who developed GDM in fish oil + probiotics-group compared to fish oil + placebo-group. The concentrations of s-phIGFBP-1 (635.9 ± 315.3 ng/mL vs. 753.2 ± 335.1 ng/mL,

conclusionsThe intervention per se had no impact on the proteins, but obesity and GDM may modify the effect. IGFBPs may affect the development of GDM.

Indexed as

AdultDiabetes, GestationalDietary SupplementsDouble-Blind MethodFemaleFish OilsHumansInflammationInsulin-Like Growth Factor Binding Protein 1Matrix Metalloproteinase 8ObesityPregnancyProbioticsFish OilsIGFBP1 protein, humanInsulin-Like Growth Factor Binding Protein 1Matrix Metalloproteinase 8MMP8 protein, humanIGFBP-1low-grade inflammationMMP-8obesitypregnancy

Identifiers

PMID33375174
PMCPMC7822218
OpenAlexW3116275926

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.