Evidence map›Paper›PMID 33376222›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Macrophage LC3-associated phagocytosis is an immune defense against

Megumi Inomata, Shuying Xu, Pallavi Chandra, Simin N Meydani, Genzou Takemura, Jennifer A Philips, John M Leong

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 3 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Rubicon modulates neuroimmune responses following traumatic brain injury.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
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  10. Prophylactic immune priming with heat-killedFrontiers in immunology · 2026
    Article
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  13. Review
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  18. Article
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  20. Observational

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Megumi InomataDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.ORCID 0000-0003-2409-2694
Shuying XuDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.ORCID 0000-0003-4572-8663
Pallavi ChandraDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-6301-7617
Simin N MeydaniJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111.
Genzou TakemuraDepartment of Internal Medicine, Asahi University School of Dentistry, Mizuho, 501-0296 Gifu, Japan.
Jennifer A PhilipsDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-9476-0240
John M LeongDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111; john.leong@tufts.edu.
Tufts University · USWashington University in St. Louis · USAsahi University · JP

Funding

Mechanisms of Innate Immune Evasion by Mycobacterium TuberculosisR01AI130454 · NIAID · WASHINGTON UNIVERSITY · PI JENNIFER A PHILIPS · 2017 to 2026
$5.9M
THE ROLE OF ESCRT IN MACROPHAGE RESISTANCE TO MYCOBACTERIAR01AI087682 · NIAID · WASHINGTON UNIVERSITY · PI PHILIPS, JENNIFER A · 2011 to 2022
$4.9M
NIAID NIH HHS R01 AI087682NIAID NIH HHS R01 AI130454
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

PhagocytosisAgingAnimalsAutophagyBacterial ProteinsHost-Pathogen InteractionsLipidsMacrophagesMaleMiceMice, Inbred C57BLMicrobial ViabilityMicrotubule-Associated ProteinsRAW 264.7 CellsReactive Oxygen SpeciesStreptococcus pneumoniaeBacterial ProteinsLipidsMap1lc3b protein, mouseMicrotubule-Associated ProteinsplY protein, Streptococcus pneumoniaeReactive Oxygen SpeciesStreptolysinsagingautophagybone-marrow-derived macrophagesLC3-associated phagocytosisStreptococcus pneumoniae

Identifiers

PMID33376222
PMCPMC7776987
OpenAlexW3114289696

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.