Evidence map›Paper›PMID 33380271›Full record

ArticleEpigenetics2021

Exposure to extracellular vesicles from

Min Kyung Lee, David A Armstrong, Haley F Hazlett, John A Dessaint, Diane L Mellinger, Daniel S Aridgides, Brock C Christensen, Alix Ashare

Open access · bronzeAbstract read
In one paragraph

Article in Epigenetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  6. Article
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  8. Article
  9. Review
  10. Extracellular Vesicles ofAntibiotics (Basel, Switzerland) · 2023
    Review
  11. Review
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  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Min Kyung LeeDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.ORCID 0000-0001-9558-4819
David A ArmstrongDepartment of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Haley F HazlettDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.ORCID 0000-0001-9937-435X
John A DessaintDepartment of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Diane L MellingerDepartment of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Daniel S AridgidesDepartment of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.ORCID 0000-0002-6132-6472
Brock C ChristensenDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.ORCID 0000-0003-3022-426X
Alix AshareDepartment of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Dartmouth College · USDartmouth–Hitchcock Medical Center · US

Funding

Translational Research CoreP30DK117469 · NIDDK · DARTMOUTH COLLEGE · PI Robert Andrew Cramer · 2018 to 2026
$13.9M
IMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLST32AI007363 · NIAID · DARTMOUTH COLLEGE · PI Claudia V Jakubzick · 1990 to 2026
$9.5M
(PQ3) Immune epigenetic biomarkers of bladder cancer outcomesR01CA216265 · NCI · DARTMOUTH COLLEGE · PI CHRISTENSEN, BROCK CLARKE · 2017 to 2021
$2.9M
Regional Hypoxia Impacts the Heterogeneity of Inflammatory Lung DiseaseR01HL122372 · NHLBI · DARTMOUTH-HITCHCOCK CLINIC · PI ASHARE, ALIX · 2015 to 2019
$2.0M
Macrophage Pathogen Interactions in Regional Cystic Fibrosis Lung InflammationK24HL150453 · NHLBI · DARTMOUTH-HITCHCOCK CLINIC · PI ASHARE, ALIX · 2020 to 2024
$542k
NCI NIH HHS R01 CA216265NHLBI NIH HHS K24 HL150453NHLBI NIH HHS R01 HL122372NIAID NIH HHS T32 AI007363NIDDK NIH HHS P30 DK117469
6 · The paper itself

Abstract

Various pathogens use differing strategies to evade host immune response including modulating the host's epigenome. Here, we investigate if EVs secreted from

Indexed as

DNA MethylationExtracellular VesiclesCpG IslandsDeoxyribonucleasesHumansLungMacrophagesPseudomonas aeruginosaRegulatory Sequences, Nucleic AcidDeoxyribonucleasesDNA methylationextracellular vesiclesinnate immunityLung macrophagePseudomonas aeruginosa

Identifiers

PMID33380271
PMCPMC8813072
OpenAlexW3116064021

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.