Evidence map›Paper›PMID 33380580›Full record

Trial reportMedical gas research

Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study.

Ji-Bing Chen, Xiao-Feng Kong, Wei Qian, Feng Mu, Tian-Yu Lu, You-Yong Lu, Ke-Cheng Xu

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Medical gas research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. A Systematic Review of Molecular Hydrogen Therapy in Cancer Management.Asian Pacific journal of cancer prevention : APJCP · 2023
    Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Aging and lung diseases: Unraveling mechanisms and therapeutic targets.Chinese medical journal pulmonary and critical care medicine · 2025
    Review
  8. Review
  9. Molecular Hydrogen in the Treatment of Respiratory Diseases.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Article
  12. Prospects of molecular hydrogen in cancer prevention and treatment.Journal of cancer research and clinical oncology · 2024
    Review
  13. Review
  14. Review
  15. Article
  16. Local HNature communications · 2023
    Article
  17. Review
  18. Ultrasound-Driven Piezoelectrocatalytic Immunoactivation of Deep Tumor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ji-Bing ChenFuda Cancer Hospital of Jinan University; Fuda Cancer Institute, Guangzhou, Guangdong Province, China.
Xiao-Feng KongFuda Cancer Hospital of Jinan University, Guangzhou, Guangdong Province, China.
Wei QianFuda Cancer Hospital of Jinan University, Guangzhou, Guangdong Province, China.
Feng MuFuda Cancer Hospital of Jinan University, Guangzhou, Guangdong Province, China.
Tian-Yu LuFuda Cancer Hospital of Jinan University; Fuda Cancer Institute, Guangzhou, Guangdong Province, China.
You-Yong LuCentral Laboratory, Peking University Cancer Hospital, Beijing, China.
Ke-Cheng XuFuda Cancer Hospital of Jinan University; Fuda Cancer Institute, Guangzhou, Guangdong Province, China.
Fuda Cancer Hospital · CNJinan University · CNPeking University Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following standard treatments, the traditional model for enhancing anti-tumor immunity involves performing immune reconstitution (e.g., adoptive immune cell therapies or immunoenhancing drugs) to prevent recurrence. For patients with advanced non-small cell lung cancer, we report here on two objectives, the immunosenescence for advanced non-small cell lung cancer and hydrogen gas inhalation for immune reconstitution. From July 1

Indexed as

Carcinoma, Non-Small-Cell LungHydrogenImmunity, InnateLung NeoplasmsAdaptive ImmunityAdministration, InhalationAgedFemaleHumansImmunosenescenceMaleMiddle AgedHydrogenadaptive and innate immune systemgamma delta T cellhydrogen inhalationimmunosenescencenatural killer cellnatural killer T cellnon-small cell lung cancerT cell

Identifiers

PMID33380580
PMCPMC8092147
OpenAlexW3115968256

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.