ArticleNeurobiology of stress2021
The functional connectome predicts feeling of stress on regular days and during the COVID-19 pandemic.
Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroimaging insights into the psychosocial impact of the COVID-19 pandemic: a systematic review.Translational psychiatry · 2025Pooled it
- Effects of hyperbaric oxygen therapy on functional and structural connectivity in post-COVID-19 condition patients: A randomized, sham-controlled trial.NeuroImage. Clinical · 2022Trial
- Association of psychosocial stress with altered functional connectivity of large-scale brain networks in aging adults.Cognitive, affective & behavioral neuroscience · 2026Article
- Threat- and reward-related brain circuitry, perceived stress, and anxiety in adolescents during the COVID-19 pandemic: a longitudinal investigation.Social cognitive and affective neuroscience · 2024Article
- Assessing the Role of the Autonomic Nervous System as a Driver of Sleep Quality in Patients With Multiple Sclerosis: Observation Study.JMIR neurotechnology · 2024Article
- The challenges and prospects of brain-based prediction of behaviour.Nature human behaviour · 2023Review
- Pre-COVID brain functional connectome features prospectively predict emergence of distress symptoms after onset of the COVID-19 pandemic.Psychological medicine · 2023Article
- Psychological resilience mediates the protective role of default-mode network functional connectivity against COVID-19 vicarious traumatization.Translational psychiatry · 2023Article
- Multivariate resting-state functional connectomes predict and characterize obesity phenotypes.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Default Mode and Frontoparietal Network Dynamics: Associations with Familial Risk for Depression and Stress Sensitivity.Journal of mood and anxiety disorders · 2023Article
- Assessing functional connectivity differences and work-related fatigue in surviving COVID-negative patients.bioRxiv : the preprint server for biology · 2023Article
- Amygdala connectivity related to subsequent stress responses during the COVID-19 outbreak.Frontiers in psychiatry · 2023Article
- Article
- Stronger functional network connectivity and social support buffer against negative affect during the COVID-19 outbreak and after the pandemic peak.Neurobiology of stress · 2021Article
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7 authors.
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Abstract
Although many studies have explored the neural mechanism of the feeling of stress, to date, no effort has been made to establish a model capable of predicting the feeling of stress at the individual level using the resting-state functional connectome. Although individuals may be confronted with multidimensional stressors during the coronavirus disease 2019 (COVID-19) pandemic, their appraisal of the impact and severity of these events might vary. In this study, connectome-based predictive modeling (CPM) with leave-one-out cross-validation was conducted to predict individual perceived stress (PS) from whole-brain functional connectivity data from 817 participants. The results showed that the feeling of stress could be predicted by the interaction between the default model network and salience network, which are involved in emotion regulation and salience attribution, respectively. Key nodes that contributed to the prediction model comprised regions mainly located in the limbic systems and temporal lobe. Critically, the CPM model of PS based on regular days can be generalized to predict individual PS levels during the COVID-19 pandemic, which is a multidimensional, uncontrollable stressful situation. The stability of the results was demonstrated by two independent datasets. The present work not only expands existing knowledge regarding the neural mechanism of PS but also may help identify high-risk individuals in healthy populations.
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