Evidence map›Paper›PMID 33390770›Full record

ArticleInternational journal of medical sciences2021

Neuropeptide Y mediates cardiac hypertrophy through microRNA-216b/FoxO4 signaling pathway.

Jinghao Wang, Dan Hao, Lingfeng Zeng, Qianhui Zhang, Wei Huang

Open access · goldAbstract read
In one paragraph

Article in International journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Neuropeptide Y as a risk factor for cardiorenal disease and cognitive dysfunction in chronic kidney disease: translational opportunities and challenges.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Article
  3. Article
  4. Role of EZH2-mediated abnormal histone H3K27me3 methylation in pressure overload-induced cardiac remodeling in mice.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jinghao WangDepartment of Pharmacy, the First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
Dan HaoDepartment of Cardiology, the First Hospital of Harbin, Harbin 150010, China.
Lingfeng ZengDepartment of Pharmacy, the First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
Qianhui ZhangDepartment of Pharmacology, Harbin Medical University-Daqing, Daqing, Heilongjiang 163319, China.
Wei HuangDepartment of Pharmacology, Harbin Medical University-Daqing, Daqing, Heilongjiang 163319, China.
Daqing City People's Hospital · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac hypertrophy (CH) is a major risk factor for heart failure accompanied by maladaptive cardiac remodeling. The role and potential mechanism of neuropeptide Y (NPY) in CH are still unclear. We will explore the role and the mechanism of NPY inactivation (NPY-I) in CH caused by pressure overload. Abdominal aortic constriction (AAC) was used to induce CH model in rats. NPY or angiotensin II (Ang II) was used to trigger CH model

Indexed as

Angiotensin IIAnimalsArginineCardiomegalyCells, CulturedDisease Models, AnimalForkhead Transcription FactorsHumansMaleMicroRNAsMyocardiumMyocytes, CardiacNeuropeptide YPrimary Cell CultureRatsReceptors, G-Protein-CoupledAngiotensin IIArginineBIBO 3304Forkhead Transcription FactorsFOXO4 protein, ratMicroRNAsMIRN216 microRNA, ratNeuropeptide YNpy1r protein, ratReceptors, G-Protein-CoupledReceptors, NeuropeptideCardiac hypertrophyFoxO4miR-216bNeuropeptide YNPY1R

Identifiers

PMID33390770
PMCPMC7738963
OpenAlexW3097102678

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.