Evidence map›Paper›PMID 33392015›Full record

ArticleQuantitative imaging in medicine and surgery2021

670 nm photobiomodulation improves the mitochondrial redox state of diabetic wounds.

Shima Mehrvar, Soudeh Mostaghimi, Farnaz H Foomani, Betsy Abroe, Janis T Eells, Sandeep Gopalakrishnan, Mahsa Ranji

Open access · diamondAbstract read
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Therapeutic Potential of Photobiomodulation for Chronic Kidney Disease.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Article
  10. Optical Metabolic Imaging of Mitochondrial Dysfunction on HADH Mutant Newborn Rat Hearts.IEEE journal of translational engineering in health and medicine · 2021
    Article
  11. Photobiomodulation studies on diabetic wound healing: An insight into the inflammatory pathway in diabetic wound healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shima MehrvarBiophotonics Lab, Department of Electrical Engineering, University of Wisconsin Milwaukee, Milwaukee, WI, USA.
Soudeh MostaghimiBiophotonics Lab, Department of Electrical Engineering, University of Wisconsin Milwaukee, Milwaukee, WI, USA.
Farnaz H FoomaniBiophotonics Lab, Department of Electrical Engineering, University of Wisconsin Milwaukee, Milwaukee, WI, USA.
Betsy AbroeCollege of Nursing, University of Wisconsin Milwaukee, Milwaukee, WI, USA.
Janis T EellsDepartment of Biomedical Sciences, University of Wisconsin Milwaukee, Milwaukee, WI, USA.
Sandeep GopalakrishnanCollege of Nursing, University of Wisconsin Milwaukee, Milwaukee, WI, USA.
Mahsa RanjiBiophotonics Lab, Department of Electrical Engineering, University of Wisconsin Milwaukee, Milwaukee, WI, USA.
University of Wisconsin–Milwaukee · US

Funding

Implementing a novel multimode 3D retinal imaging system to investigate metabolism and vascular disruptions in diabetic retinopathyR15EY031533 · NEI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI RANJI, MAHSA · 2020 to 2020
$445k
NEI NIH HHS R15 EY031533
6 · The paper itself

Abstract

backgroundPhotobiomodulation (PBM) by far-red (FR) to near-infrared (NIR) light has been demonstrated to accelerate diabetic wound healing in preclinical and clinical studies. Mitochondrial dysfunction and oxidative stress play key roles in impaired diabetic wound healing, and the effect of PBM on the metabolic state of diabetic wounds remains to be elucidated.

methodsIn this study, a custom-designed

resultsUsing an excisional model of wound healing, we demonstrated that 670 nm (FR) PBM improved mitochondrial bioenergetics and stimulated the rate of wound healing in diabetic

conclusionsWe conclude that the increase in mitochondrial RR and the related decrease in oxidative stress may be an important factor in FR-PBM mediated acceleration of wound healing in diabetic mice.

Indexed as

diabetic woundsflavin adenine dinucleotide (FAD)nicotinamide adenine dinucleotide (NADH)photobiomodulation (PBM)Redox state

Identifiers

PMID33392015
PMCPMC7719930
OpenAlexW3079711265

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.