Evidence map›Paper›PMID 33394235›Full record

ArticleMolecular biology reports2021

Different roles of Numb-p72 and Numb-p65 on the trafficking of metabotropic glutamate receptor 5.

Na Wang, Dan-Dan Wang, Xiaolin Hou, Xiumao Li, Ying Shen

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Na Wang *School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, People's Republic of China. wangna@zju.edu.cn.
Dan-Dan Wang *General Hospital of NingXia Medical University, Yinchuan, Ningxia, People's Republic of China.
Xiaolin HouGeneral Hospital of NingXia Medical University, Yinchuan, Ningxia, People's Republic of China.
Xiumao LiDepartment of Orthopedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Ying ShenDepartment of Physiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Ningxia Medical University · CNZhejiang University · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously reported that Numb, a protein localized to clathrin-coated vesicles, regulates the membrane expression of metabotropic glutamate receptor 5 (mGluR5) and is critical to social behaviors. However, the distinct actions of Numb isoforms on mGluR5 have not been investigated. Here, we showed that the expression patterns of Numb-p72 and Numb-p65, two important isoforms of Numb, were distinct in HEK293T cells. Numb-p72, but not Numb-p65, bound to mGluR5α, and enhanced mGluR5 membrane expression by inhibiting its internalization. Our results suggest that a complete structure is required for Numb to bind to mGluR5 and to modulate mGluR5 trafficking.

Indexed as

Cell MovementHEK293 CellsHippocampusHumansMembrane ProteinsNerve Tissue ProteinsNeuronsProtein BindingProtein IsoformsProtein TransportReceptor, Metabotropic Glutamate 5Membrane ProteinsNerve Tissue ProteinsNUMB protein, humanProtein IsoformsReceptor, Metabotropic Glutamate 5InternalizationMetabotropic glutamate receptorNumbNumb-p72Trafficking

Identifiers

PMID33394235
OpenAlexW3118634524

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.