Evidence map›Paper›PMID 33394283›Full record

ArticleFish physiology and biochemistry2021

Tryptophan-tagged peptide from serine threonine-protein kinase of Channa striatus improves antioxidant defence in L6 myotubes and attenuates caspase 3-dependent apoptotic response in zebrafish larvae.

Praveen Kumar Issac, Christy Lite, Ajay Guru, Manikandan Velayutham, Giva Kuppusamy, N T Saraswathi, Ebtesam M Al Olayan, Abeer S Aloufi, Mohamed A Elokaby, Preetham Elumalai and 2 more

Abstract read
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In one paragraph

Article in Fish physiology and biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 45 citations in OpenAlex.

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  8. Histone acetyltransferases derived RW20 protects and promotes rapid clearance of Pseudomonas aeruginosa in zebrafish larvae.International microbiology : the official journal of the Spanish Society for Microbiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Praveen Kumar IssacSRM Research Institute, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603 203, India.
Christy LiteEndocrine and Exposome Laboratory, Department of Zoology, Madras Christian College, Tambaram, Chennai, Tamil Nadu, 600 059, India.
Ajay GuruSRM Research Institute, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603 203, India.
Manikandan VelayuthamSRM Research Institute, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603 203, India.
Giva KuppusamyInnovation and Technology Advancement Department, GK Aqua Sdn Bhd, Lot 563 Kg Sg Machang Ulu, 71750, Lenggeng, Negeri Sembilan, Malaysia.
N T SaraswathiMolecular Biophysics Lab, School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, Tamil Nadu, 613 401, India.
Ebtesam M Al OlayanDepartment of Zoology, Faculty of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Abeer S AloufiDepartment of Zoology, Vaccines Research Unit, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Mohamed A ElokabyAquaculture Division, National Institute of Oceanography and Fisheries (NIOF), Alexandria, 21556, Egypt.
Preetham ElumalaiSchool of Processing Technology, Kerala University of Fisheries and Ocean Studies, Panangad, Kerala, India.
Aziz ArshadInternational Institute of Aquaculture and Aquatic Sciences (I-AQUAS), Universiti Putra Malaysia, 71050, Port Dickson, Negeri Sembilan, Malaysia.
Jesu ArockiarajSRM Research Institute, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603 203, India. jesuaraj@hotmail.com.ORCID http://orcid.org/0000-0002-0240-7141
SRM Institute of Science and Technology · INKing Saud University · SAKerala University of Fisheries and Ocean Studies · INNational Institute of Oceanography and Fisheries · EGSASTRA University · INUniversiti Putra Malaysia · MY

Funding

Deanship of Scientific Research, King Saud University RSP-2020/111Faculti Sains, Universiti Putra Malaysia LRGS/1/2019/UPM/1
6 · The paper itself

Abstract

This study reports the antioxidant property and molecular mechanism of a tryptophan-tagged peptide derived from a teleost fish Channa striatus of serine threonine-protein kinase (STPK). The peptide was tagged with tryptophan to enhance the antioxidant property of STPK and named as IW13. The antioxidant activity of IW13 peptide was investigated using in vitro methods such as DPPH, ABTS, superoxide anion radical scavenging and hydrogen peroxide scavenging assay. Furthermore, to investigate the toxicity and dose response of IW13 peptide on antioxidant defence in vitro, L6 myotubes were induced with generic oxidative stress due to exposure of hydrogen peroxide (H

Indexed as

AnimalsAntioxidantsApoptosisCaspase 3Cell LineCell SurvivalFishesFish ProteinsLarvaLipid PeroxidationMuscle Fibers, SkeletalProtein Serine-Threonine KinasesReactive Oxygen SpeciesTryptophanAntioxidantsCaspase 3Fish ProteinsProtein Serine-Threonine KinasesReactive Oxygen SpeciesTryptophanAntioxidant peptideChanna striatusOxidative stressSerine threonine-protein kinaseTryptophanZebrafish larvae

Identifiers

PMID33394283
OpenAlexW3120791181

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.