ArticleGenes2020
Transcriptomic Analysis of a Diabetic Skin-Humanized Mouse Model Dissects Molecular Pathways Underlying the Delayed Wound Healing Response.
Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Current trends in single-cell RNA sequencing applications in diabetes mellitus.FEBS open bio · 2025Review
- Identifying pyroptosis-related genes as novel therapeutic targets in diabetic foot ulceration.Diabetology & metabolic syndrome · 2025Article
- A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage.Nature communications · 2025Article
- Systemic immune response alteration in patients with severe pressure ulcers.Scientific reports · 2025Article
- Identification of compounds to promote diabetic wound healing based on transcriptome signature.Frontiers in pharmacology · 2025Article
- Identification of biomarkers and potential drug targets in DFU based on fundamental experiments and multi-omics joint analysis.Frontiers in pharmacology · 2025Article
- Assessment of potential genetic markers for diabetic foot ulcer among Moscow residents.Endocrine · 2024Article
- Robust classification of wound healing stages in both mice and humans for acute and burn wounds based on transcriptomic data.BMC bioinformatics · 2023Article
- A Review of Genes Involved in Wound Healing.Medical journal of the Islamic Republic of Iran · 2023Review
- Notoginsenoside R1 Facilitated Wound Healing in High-Fat Diet/Streptozotocin-Induced Diabetic Rats.Oxidative medicine and cellular longevity · 2022Article
- Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data.Computational and structural biotechnology journal · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Defective healing leading to cutaneous ulcer formation is one of the most feared complications of diabetes due to its consequences on patients' quality of life and on the healthcare system. A more in-depth analysis of the underlying molecular pathophysiology is required to develop effective healing-promoting therapies for those patients. Major architectural and functional differences with human epidermis limit extrapolation of results coming from rodents and other small mammal-healing models. Therefore, the search for reliable humanized models has become mandatory. Previously, we developed a diabetes-induced delayed humanized wound healing model that faithfully recapitulated the major histological features of such skin repair-deficient condition. Herein, we present the results of a transcriptomic and functional enrichment analysis followed by a mechanistic analysis performed in such humanized wound healing model. The deregulation of genes implicated in functions such as angiogenesis, apoptosis, and inflammatory signaling processes were evidenced, confirming published data in diabetic patients that in fact might also underlie some of the histological features previously reported in the delayed skin-humanized healing model. Altogether, these molecular findings support the utility of such preclinical model as a valuable tool to gain insight into the molecular basis of the delayed diabetic healing with potential impact in the translational medicine field.
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