Trial reportBMC medicine2021
Targeting body composition in an older population: do changes in movement behaviours matter? Longitudinal analyses in the PREDIMED-Plus trial.
Trial report in BMC medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Sedentary behavior with atrial fibrillation-related biomarkers in overweight or obese adults.BMC cardiovascular disorders · 2026Trial
- Unpacking adiposity: a narrative critical appraisal of diverse obesity definitions.Diabetology & metabolic syndrome · 2026Review
- Isotemporal substitution of physical activity patterns and sitting time with obesity indicators among workers in São Paulo.Scientific reports · 2025Article
- Article
- Prevalence and correlates of meeting 24-hour movement guidelines and its associations with physical fitness and depressive symptoms among adults: a provincial surveillance in China.BMC public health · 2024Article
- Replacing sedentary time for physical activity: Does intensity matter for body composition in oldest-old adults?Journal of sports sciences · 2024Article
- Effect of Baduanjin exercise on primary osteoporosis: study protocol for randomized controlled trial.BMC complementary medicine and therapies · 2023Article
- Association of the COVID-19 pandemic with changes in objectively measured sedentary behaviour and adiposity.International journal of obesity (2005) · 2023Article
- Development and Evaluation of a Digital Health Intervention to Prevent Type 2 Diabetes in Primary Care: The PREDIABETEXT Study Protocol for a Randomised Clinical Trial.International journal of environmental research and public health · 2022Article
- Metabolic syndrome and its association with changes in modifiable risk factors: Epifloripa aging study.Journal of diabetes and metabolic disorders · 2022Article
- Adipokines Level and Cognitive Function-Disturbance in Homeostasis in Older People with Poorly Managed Hypertension: A Pilot Study.International journal of environmental research and public health · 2022Article
- Association of sedentary behaviour and physical activity with cardiometabolic health in Japanese adults.Scientific reports · 2022Article
- Lifestyle elements and risk of metabolic syndrome in adults.PloS one · 2022Article
- Impact of current or past physical activity level on functional capacities and body composition among elderly people: a cross-sectional analysis from the YMCA study.Archives of public health = Archives belges de sante publique · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundThe optimal distribution between physical activity (PA) levels and sedentary behaviour (SB) for the greatest benefits for body composition among older adults with overweight/obesity and chronic health conditions remains unclear. We aimed to determine the prospective association between changes in PA and in SB with concurrent changes in body composition and to examine whether reallocating inactive time into different physical activity levels was associated with 12-month change to body composition in older adults.
methodsLongitudinal assessment nested in the PREDIMED-Plus trial. A subsample (n = 1564) of men and women (age 55-75 years) with overweight/obesity and metabolic syndrome from both arms of the PREDIMED-Plus trial was included in the present analysis. Participants were followed up at 6 and 12 months. Physical activity and SB were assessed using validated questionnaires. Out of 1564 participants, 388 wore an accelerometer to objectively measure inactive time and PA over a 7-day period. At each time point, participants' body composition was measured using dual-energy X-ray absorptiometry (DXA). Standard covariate-adjusted and isotemporal substitution modelling were applied to linear mixed-effects models.
resultsIncreasing 30 min of total PA and moderate-to-vigorous physical activity (MVPA) was associated with significant reductions in body fat (β - 0.07% and - 0.08%) and visceral adipose tissue (VAT) (- 13.9 g, and - 15.6 g) at 12 months (all p values < 0.001). Reallocating 30 min of inactive time to MVPA was associated with reductions in body fat and VAT and with an increase in muscle mass and muscle-to-fat mass ratio (all p values < 0.001).
conclusionsAt 12 months, increasing total PA and MVPA and reducing total SB and TV-viewing SB were associated with improved body composition in participants with overweight or obesity, and metabolic syndrome. This was also observed when substituting 30 min of inactive time with total PA, LPA and MVPA, with the greatest benefits observed with MVPA.
trial registrationInternational Standard Randomized Controlled Trial (ISRCTN), 89898870 . Retrospectively registered on 24 July 2014.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.