Evidence map›Paper›PMID 33404837›Full record

ReviewCell and tissue research2021

Untangling the wires: development of sparse, distributed connectivity in the mushroom body calyx.

Vanessa M Puñal, Maria Ahmed, Emma M Thornton-Kolbe, E Josephine Clowney

Abstract readReview
In one paragraph

Review in Cell and tissue research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Modular presynaptic assemblages scale to postsynaptic partner number.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Future avenues inLearning & memory (Cold Spring Harbor, N.Y.) · 2024
    Review
  7. Diversity of visual inputs to Kenyon cells of thebioRxiv : the preprint server for biology · 2023
    Article
  8. Article
  9. Hacking brain development to test models of sensory coding.bioRxiv : the preprint server for biology · 2023
    Article
  10. The making of the Drosophila mushroom body.Frontiers in physiology · 2023
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vanessa M PuñalDepartment of Molecular, Cellular & Developmental Biology, The University of Michigan, Ann Arbor, MI, 48109, USA.
Maria AhmedDepartment of Molecular, Cellular & Developmental Biology, The University of Michigan, Ann Arbor, MI, 48109, USA.
Emma M Thornton-KolbeDepartment of Molecular, Cellular & Developmental Biology, The University of Michigan, Ann Arbor, MI, 48109, USA.
E Josephine ClowneyDepartment of Molecular, Cellular & Developmental Biology, The University of Michigan, Ann Arbor, MI, 48109, USA. jclowney@umich.edu.ORCID http://orcid.org/0000-0002-9150-9464

Funding

Michigan IRACDA: Training Future Professors of Engineering and PhysiologyK12GM111725 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROOKS, SUSAN V, SEPT, DAVID · 2016 to 2025
$7.9M
Generation and manipulation of combinatorial connectivity in olfactory perceptionR01DC018032 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eleanor Josephine Clowney · 2020 to 2026
$2.7M
Alfred P. Sloan Foundation Research Scholar in NeuroscienceNIDCD NIH HHS R01 DC018032NIDCD NIH HHS R01DC018032NIGMS NIH HHS K12 GM111725NIH HHS K12-GM111725Rita Allen Foundation Milton Cassell Scholar
6 · The paper itself

Abstract

Appropriate perception and representation of sensory stimuli pose an everyday challenge to the brain. In order to represent the wide and unpredictable array of environmental stimuli, principle neurons of associative learning regions receive sparse, combinatorial sensory inputs. Despite the broad role of such networks in sensory neural circuits, the developmental mechanisms underlying their emergence are not well understood. As mammalian sensory coding regions are numerically complex and lack the accessibility of simpler invertebrate systems, we chose to focus this review on the numerically simpler, yet functionally similar, Drosophila mushroom body calyx. We bring together current knowledge about the cellular and molecular mechanisms orchestrating calyx development, in addition to drawing insights from literature regarding construction of sparse wiring in the mammalian cerebellum. From this, we formulate hypotheses to guide our future understanding of the development of this critical perceptual center.

Indexed as

AnimalsBrainMushroom BodiesCalyxDevelopmentMushroom bodyPerceptionSparse wiring

Identifiers

PMID33404837
PMCPMC9835099

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.