SynthesisBMC genomics2021
A meta-analysis of genome-wide association studies for average daily gain and lean meat percentage in two Duroc pig populations.
Synthesis in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Multi-ancestry genome-wide association meta-analysis identifies candidate genes for computed tomography-based carcass composition traits in pigs.Genetics, selection, evolution : GSE · 2025Pooled it
- A meta-analysis of genome-wide association studies revealed significant QTL and candidate genes for loin muscle area in three breeding pigs.Scientific reports · 2025Pooled it
- Meta-analysis of genome-wide association studies uncovers shared candidate genes across breeds for pig fatness trait.BMC genomics · 2022Pooled it
- Multi-Omics Integration Identifies ABCD4 as a Key Regulator of Backfat Thickness and Lipid Deposition in Pietrain Pigs.Animal genetics · 2026Article
- Impact of increasing market pig weights in North America: a comprehensive review.Journal of animal science and biotechnology · 2026Review
- Integrative multi-omics analysis identifies GNAZ and SLC5A4 as critical regulators of gestation length in Large White pigs.Genetics, selection, evolution : GSE · 2026Article
- Review
- Single- and multiple-locus model genome-wide association study for growth traits in Dongliao black pigs.Animal bioscience · 2025Article
- Productive performance and carcass quality of pigs from different sire lines under commercial production conditions.Veterinary and animal science · 2025Article
- Origins, Dispersal, and Impact: Bidirectional Introgression Between Chinese and European Pig Populations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Assessing the relationship between the gut microbiota and growth traits in Chinese indigenous pig breeds.BMC veterinary research · 2025Article
- Genome-Wide Association Studies of Body Weight and Average Daily Gain in Chinese Dongliao Black Pigs.International journal of molecular sciences · 2025Article
- Capturing resilience from phenotypic deviations: a case study using feed consumption and whole genome data in pigs.BMC genomics · 2024Article
- Empirical versus estimated accuracy of imputation: optimising filtering thresholds for sequence imputation.Genetics, selection, evolution : GSE · 2024Article
- Deep Learning-Based Automated Approach for Determination of Pig Carcass Traits.Animals : an open access journal from MDPI · 2024Article
- Structural variant landscapes reveal convergent signatures of evolution in sheep and goats.Genome biology · 2024Article
- Genome-wide association study to reveal new candidate genes using single-step approaches for productive traits of Yorkshire pig in Korea.Animal bioscience · 2024Article
- Detection of Runs of Homozygosity and Identification of Candidate Genes in the Whole Genome of Tunchang Pigs.Animals : an open access journal from MDPI · 2024Article
- Genome-wide association analysis unveils candidate genes and loci associated with aplasia cutis congenita in pigs.BMC genomics · 2023Article
- An Analysis of a Transposable Element Expression Atlas during 27 Developmental Stages in Porcine Skeletal Muscle: Unveiling Molecular Insights into Pork Production Traits.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAverage daily gain (ADG) and lean meat percentage (LMP) are the main production performance indicators of pigs. Nevertheless, the genetic architecture of ADG and LMP is still elusive. Here, we conducted genome-wide association studies (GWAS) and meta-analysis for ADG and LMP in 3770 American and 2090 Canadian Duroc pigs.
resultsIn the American Duroc pigs, one novel pleiotropic quantitative trait locus (QTL) on Sus scrofa chromosome 1 (SSC1) was identified to be associated with ADG and LMP, which spans 2.53 Mb (from 159.66 to 162.19 Mb). In the Canadian Duroc pigs, two novel QTLs on SSC1 were detected for LMP, which were situated in 3.86 Mb (from 157.99 to 161.85 Mb) and 555 kb (from 37.63 to 38.19 Mb) regions. The meta-analysis identified ten and 20 additional SNPs for ADG and LMP, respectively. Finally, four genes (PHLPP1, STC1, DYRK1B, and PIK3C2A) were detected to be associated with ADG and/or LMP. Further bioinformatics analysis showed that the candidate genes for ADG are mainly involved in bone growth and development, whereas the candidate genes for LMP mainly participated in adipose tissue and muscle tissue growth and development.
conclusionsWe performed GWAS and meta-analysis for ADG and LMP based on a large sample size consisting of two Duroc pig populations. One pleiotropic QTL that shared a 2.19 Mb haplotype block from 159.66 to 161.85 Mb on SSC1 was found to affect ADG and LMP in the two Duroc pig populations. Furthermore, the combination of single-population and meta-analysis of GWAS improved the efficiency of detecting additional SNPs for the analyzed traits. Our results provide new insights into the genetic architecture of ADG and LMP traits in pigs. Moreover, some significant SNPs associated with ADG and/or LMP in this study may be useful for marker-assisted selection in pig breeding.
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