Evidence map›Paper›PMID 33407390›Full record

ArticleBMC medical informatics and decision making2021

Predicting cardiovascular health trajectories in time-series electronic health records with LSTM models.

Aixia Guo, Rahmatollah Beheshti, Yosef M Khan, James R Langabeer, Randi E Foraker

Open access · goldAbstract read
In one paragraph

Article in BMC medical informatics and decision making, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Association of bone fracture with 30-year body mass index (BMI) trajectories: findings from the Framingham Heart Study : Bone fracture and 30-year BMI trajectories.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Subtyping Patients With Chronic Disease Using Longitudinal BMI Patterns.IEEE journal of biomedical and health informatics · 2023
    Article
  11. Estimation of Life's Essential 8 Score with Incomplete Data of Individual Metrics.medRxiv : the preprint server for health sciences · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Aixia GuoInstitute for Informatics (I2), Washington University School of Medicine, 600 S. Taylor Avenue, Suite 102, St. Louis, MO, 63110, USA. aixia.guo@wustl.edu.ORCID 0000-0003-0542-0920
Rahmatollah BeheshtiDepartment of Computer & Information Sciences, Data Science Institute, University of Delaware, Newark, DE, USA.
Yosef M KhanHealth Informatics and Analytics, Centers for Health Metrics and Evaluation, American Heart Association, Dallas, TX, USA.
James R LangabeerSchool of Biomedical Informatics, Health Science Center at Houston, The University of Texas, Houston, TX, USA.
Randi E ForakerInstitute for Informatics (I2), Washington University School of Medicine, 600 S. Taylor Avenue, Suite 102, St. Louis, MO, 63110, USA.
Washington University in St. Louis · USAmerican Heart Association · USThe University of Texas Health Science Center at Houston · USUniversity of Delaware · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiovascular disease (CVD) is the leading cause of death in the United States (US). Better cardiovascular health (CVH) is associated with CVD prevention. Predicting future CVH levels may help providers better manage patients' CVH. We hypothesized that CVH measures can be predicted based on previous measurements from longitudinal electronic health record (EHR) data.

methodsThe Guideline Advantage (TGA) dataset was used and contained EHR data from 70 outpatient clinics across the United States (US). We studied predictions of 5 CVH submetrics: smoking status (SMK), body mass index (BMI), blood pressure (BP), hemoglobin A1c (A1C), and low-density lipoprotein (LDL). We applied embedding techniques and long short-term memory (LSTM) networks - to predict future CVH category levels from all the previous CVH measurements of 216,445 unique patients for each CVH submetric.

resultsThe LSTM model performance was evaluated by the area under the receiver operator curve (AUROC): the micro-average AUROC was 0.99 for SMK prediction; 0.97 for BMI; 0.84 for BP; 0.91 for A1C; and 0.93 for LDL prediction. Model performance was not improved by using all 5 submetric measures compared with using single submetric measures.

conclusionsWe suggest that future CVH levels can be predicted using previous CVH measurements for each submetric, which has implications for population cardiovascular health management. Predicting patients' future CVH levels might directly increase patient CVH health and thus quality of life, while also indirectly decreasing the burden and cost for clinical health system caused by CVD and cancers.

Indexed as

Cardiovascular DiseasesElectronic Health RecordsBlood PressureCross-Sectional StudiesHealth StatusHumansQuality of LifeRisk FactorsUnited StatesCardiovascular health (CVH)CVH predictionLSTM modelsPrecision medicineThe guideline advantage (TGA)

Identifiers

PMID33407390
PMCPMC7789405
OpenAlexW3118299366

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.