Evidence map›Paper›PMID 33408171›Full record

ArticleJournal of virology2021

Transcriptional Analysis of Lymphoid Tissues from Infected Nonhuman Primates Reveals the Basis for Attenuation and Immunogenicity of an Ebola Virus Encoding a Mutant VP35 Protein.

Amanda Pinski, Courtney Woolsey, Allen Jankeel, Robert Cross, Christopher F Basler, Thomas Geisbert, Ilhem Messaoudi

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Recent Advances in Therapeutic Approaches Against Ebola Virus Infection.Recent advances in anti-infective drug discovery · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Amanda Pinski *Department of Molecular Biology and Biochemistry, College of Biological Sciences, University of California, Irvine, Irvine, California, USA.
Courtney Woolsey *Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Allen JankeelDepartment of Molecular Biology and Biochemistry, College of Biological Sciences, University of California, Irvine, Irvine, California, USA.
Robert CrossDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Christopher F BaslerCenter for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA cbasler@gsu.edu twgeisbe@utmb.edu imessaou@uci.edu.ORCID 0000-0003-4195-425X
Thomas GeisbertDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA cbasler@gsu.edu twgeisbe@utmb.edu imessaou@uci.edu.
Ilhem MessaoudiDepartment of Molecular Biology and Biochemistry, College of Biological Sciences, University of California, Irvine, Irvine, California, USA cbasler@gsu.edu twgeisbe@utmb.edu imessaou@uci.edu.ORCID 0000-0003-3203-2405
The University of Texas Medical Branch at Galveston · USUniversity of California, Irvine · USGeorgia State University · US

Funding

Regulatory Compliance Core - Galveston National Laboratory BSL4 OperationsUC7AI094660 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Gene Garrard Olinger · 2011 to 2026
$208.8M
Supplemental Research Project (SRP)U19AI109711 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ELDRIDGE, JOHN HAYWARD · 2014 to 2018
$26.6M
Molecular mechanisms of immune dysregulation by filoviral interferon U19AI109945 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BASLER, CHRISTOPHER F · 2014 to 2018
$9.5M
Generation of A Safe Yet Fully Replication-Competent FilovirusR21AI139934 · NIAID · GEORGIA STATE UNIVERSITY · PI BASLER, CHRISTOPHER F · 2018 to 2019
$439k
NIAID NIH HHS R21 AI139934NIAID NIH HHS U19 AI109711NIAID NIH HHS U19 AI109945NIAID NIH HHS UC7 AI094660
6 · The paper itself

Abstract

Infection with

Indexed as

Adaptive ImmunityAnimalsAntiviral AgentsEbolavirusGene Expression RegulationHemorrhagic Fever, EbolaLymphoid TissueMacaca fascicularisMutationSpleenTranscriptomeViral Regulatory and Accessory ProteinsAntiviral AgentsViral Regulatory and Accessory ProteinsVP35 protein, filovirusEbola virus diseasehost responseimmunitylymphoid tissuepathogenesistranscriptionalviral attenuationVP35

Identifiers

PMID33408171
PMCPMC8094945
OpenAlexW3120577089

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.