Evidence map›Paper›PMID 33408364›Full record

Trial reportScientific reports2021

Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults.

D R Michael, T S Davies, A A Jack, G Masetti, J R Marchesi, D Wang, B H Mullish, S F Plummer

2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05710055 nacompletednot on this mapstarted 2023, after this paper: background citation

A Randomized, Double-blind, Controlled Trial to Evaluate the Efficacy on Overweight With Oral Supplemenation of Probiotics and Prebiotics

TypeinterventionalSponsorShenzhen Precision Health Food Technology Co. Ltd.,Ran2023 to 2023Enrolled200ConditionsOverweightArmsStudy product A (Wonderlab wonder4shape), Study product B (Wonderlab wonder4shape), Study product C (Wonderlab wonder4shape), Study product D
NCT07073781 narecruitingnot on this mapstarted 2025, after this paper: background citation

A Double-blind Placebo-controlled Exploratory Trial to Assess the Impact of Daily Lab4P Probiotic Supplementation on Cognitive Performance and Metabolic Regulation in Overweight Young Adults With Impaired Glucose Regulation

TypeinterventionalSponsorLeeds Beckett UniversityRan2025 to 2026Enrolled70ConditionsImpaired Glucose Regulation, Impaired Glucose Tolerance (Prediabetes), Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Overweight (BMI &gtArmsLab4p Probiotic Consortium, Placebo
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Effects ofFrontiers in microbiology · 2025
    Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Biomedicines · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. The Efficacy ofMetabolites · 2024
    Article
  11. Probiotics: truths and illusions.Iranian journal of microbiology · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

D R MichaelCultech Limited, Unit 2 Christchurch Road, Baglan Industrial Park, Port Talbot, UK. darynm@cultech.co.uk.
T S DaviesCultech Limited, Unit 2 Christchurch Road, Baglan Industrial Park, Port Talbot, UK.
A A JackCultech Limited, Unit 2 Christchurch Road, Baglan Industrial Park, Port Talbot, UK.
G MasettiCultech Limited, Unit 2 Christchurch Road, Baglan Industrial Park, Port Talbot, UK.
J R MarchesiSchool of Biosciences, Cardiff University, Cardiff, UK.
D WangDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
B H MullishDivision of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.
S F PlummerCultech Limited, Unit 2 Christchurch Road, Baglan Industrial Park, Port Talbot, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This 9-month randomised, parallel, double-blind, single-centre, placebo-controlled study (PROBE, ISRCTN18030882) assessed the impact of probiotic supplementation on bodyweight. Seventy overweight Bulgarian participants aged 45-65 years with BMI 25-29.9 kg/m

Indexed as

Dietary SupplementsBifidobacteriumBlood PressureBody SizeBody WeightBulgariaDouble-Blind MethodFemaleHumansLactobacillusMaleMiddle AgedOverweightProbioticsWaist CircumferenceWeight Loss

Identifiers

PMID33408364
PMCPMC7788077

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.