Evidence map›Paper›PMID 33411501›Full record

ArticleACS chemical biology2021

The Inositol Pyrophosphate Biosynthetic Pathway of

Brian S Mantilla, Leticia D Do Amaral, Henning J Jessen, Roberto Docampo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Stable Isotopomers ofACS central science · 2022
    Article
  3. The long and winding road of reverse genetics inMicrobial cell (Graz, Austria) · 2021
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Brian S MantillaCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia 30602, United States.
Leticia D Do AmaralCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia 30602, United States.
Henning J JessenInstitute of Organic Chemistry, Faculty of Chemistry and Pharmacy, University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-1025-9484
Roberto DocampoCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0003-4229-8784
University of Georgia · USUniversity of Freiburg · DE

Funding

Calcium signaling in Trypanosoma bruceiR01AI108222 · NIAID · UNIVERSITY OF GEORGIA · PI DOCAMPO, ROBERTO · 2014 to 2017
$1.5M
Medical Research Council MR/P027989/1NIAID NIH HHS R01 AI108222
6 · The paper itself

Abstract

Inositol phosphates (IPs) are phosphorylated derivatives of myo-inositol involved in the regulation of several cellular processes through their interaction with specific proteins. Their synthesis relies on the activity of specific kinases that use ATP as phosphate donor. Here, we combined reverse genetics and liquid chromatography coupled to mass spectrometry (LC-MS) to dissect the inositol phosphate biosynthetic pathway and its metabolic intermediates in the main life cycle stages (epimastigotes, cell-derived trypomastigotes, and amastigotes) of

Indexed as

Gene Knockout TechniquesGenes, HelminthInositol PhosphatesPhosphotransferases (Alcohol Group Acceptor)Trypanosoma cruziVirulenceInositol PhosphatesPhosphotransferases (Alcohol Group Acceptor)

Identifiers

PMID33411501
PMCPMC10466500
OpenAlexW3118546501

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.