Observational studyCardiovascular diabetology2021
Associations between continuous glucose monitoring-derived metrics and arterial stiffness in Japanese patients with type 2 diabetes.
Observational study in Cardiovascular diabetology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Effects of concurrent aerobic and resistance training on vascular health in type 2 diabetes: a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Comparative effects of fixed-dose mitiglinide/voglibose combination and glimepiride on vascular endothelial function and glycemic variability in patients with type 2 diabetes: A randomized controlled trial.Journal of diabetes investigation · 2024Trial
- Association of glycation gap with hypoglycemia CGM indices, diabetic complications, and quality of life in Japanese type 2 diabetes patients.Journal of diabetes investigation · 2026Article
- Analysis of the Relationship of Glycated Hemoglobin with Subclinical Atherosclerosis and Arterial Stiffness in Non-Diabetic Patients: A Retrospective Study.Journal of clinical medicine · 2026Article
- Continuous Glucose Monitoring-Derived Metrics and Cardiovascular Risk Among People With Diabetes: Systematic Scoping Review.JMIR diabetes · 2026Review
- Continuous glucose monitoring reveals periodontitis-induced glucose variability, insulin resistance, and gut microbiota dysbiosis in mice.Scientific reports · 2025Article
- Continuous Glucose Monitoring Systems Can Meet the Challenge of Glucose Management and Beyond in Individuals with Type 2 Diabetes: An Expert Multidisciplinary Position.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Review
- Association between glycemic variability and mortality in critically ill patients with heart failure.Scientific reports · 2025Article
- Effects of switching from dipeptidyl peptidase 4 inhibitors to oral semaglutide on oxidative stress and glycemic variability in patients with type 2 diabetes: an open-label, prospective, randomized, multicenter, parallel-group comparison study.Diabetology & metabolic syndrome · 2025Article
- The importance of the time in target range (TTR) of glucose and blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Predictive value of glucose coefficient of variation for in-hospital mortality in acute myocardial infarction patients undergoing PCI: Insights from the MIMIC-IV database.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- Association between variation in hemoglobin A1c levels and diabetes therapy-related quality of life in patients with diabetes.Journal of diabetes investigation · 2024Article
- Glycemic variability is associated with sural nerve conduction velocity in outpatients with type 2 diabetes: Usefulness of a new point-of-care device for nerve conduction studies.Journal of diabetes investigation · 2024Article
- Associations between time in range and insulin secretory capacity in Japanese patients with type 2 diabetes.Scientific reports · 2024Article
- Association between glycemia risk index and arterial stiffness in type 2 diabetes.Journal of diabetes investigation · 2024Article
- Enhancement of Ambulatory Glucose Profile for Decision Assistance and Treatment Adjustments.Diagnostics (Basel, Switzerland) · 2024Article
- Effect of 24 h glucose fluctuations on 30-day and 1-year mortality in patients with acute myocardial infarction: an analysis from the MIMIC-III database.Frontiers in cardiovascular medicine · 2024Article
- Glycemic variability: Measurement, target, impact on complications of diabetes and does it really matter?Journal of diabetes investigation · 2024Review
- Continuous glucose monitoring-derived time in range and CV are associated with altered tissue characteristics of the carotid artery wall in people with type 2 diabetes.Diabetologia · 2023Observational
- Clinical and Lifestyle Determinants of Continuous Glucose Monitoring Metrics in Insulin-Treated Patients with Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2023Observational
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have suggested that high mean glucose levels and glycemic abnormalities such as glucose fluctuation and hypoglycemia accelerate the progression of atherosclerosis in patients with type 2 diabetes. Although continuous glucose monitoring (CGM) that could evaluate such glycemic abnormalities has been rapidly adopted, the associations between CGM-derived metrics and arterial stiffness are not entirely clear.
methodsThis exploratory cross-sectional study used baseline data from an ongoing prospective, multicenter, observational study with 5 years of follow-up. Study participants included 445 outpatients with type 2 diabetes and no history of apparent cardiovascular disease who underwent CGM and brachial-ankle pulse wave velocity (baPWV) measurement at baseline. Associations between CGM-derived metrics and baPWV were analyzed using multivariate regression models.
resultsIn a linear regression model, all CGM-derived metrics were significantly associated with baPWV, but HbA1c was not. Some CGM-derived metrics related to intra-day glucose variability, hyperglycemia, and hypoglycemia remained significantly associated with baPWV after adjusting for possible atherosclerotic risk factors, including HbA1c. Based on baPWV ≥ 1800 cm/s as indicative of high arterial stiffness, multivariate logistic regression found that some CGM-derived metrics related to intra-day glucose variability and hyperglycemia are significantly associated with high arterial stiffness even after adjusting for possible atherosclerotic risk factors, including HbA1c.
conclusionsMultiple CGM-derived metrics are significantly associated with baPWV and high arterial stiffness in patients with type 2 diabetes who have no history of apparent cardiovascular disease. These metrics might be useful for identifying patients at high risk of developing cardiovascular disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.