Evidence map›Paper›PMID 33414500›Full record

SynthesisMolecular psychiatry2021

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation.

Sara Sammallahti, Andrea P Cortes Hidalgo, Samuli Tuominen, Anni Malmberg, Rosa H Mulder, Kelly J Brunst, Silvia Alemany, Nancy S McBride, Paul Yousefi, Jonathan A Heiss and 41 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 5 pooled it
19.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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  19. The social origins of obesity within and across generations.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

51 authors at 20 institutions in 11 countries.

Sara Sammallahti *Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, The Netherlands.
Andrea P Cortes Hidalgo *Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7426-6181
Samuli TuominenUniversity of Helsinki, Department of Psychology and Logopedics, Helsinki, Finland.ORCID http://orcid.org/0000-0002-1879-0739
Anni MalmbergUniversity of Helsinki, Department of Psychology and Logopedics, Helsinki, Finland.
Rosa H MulderErasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, The Netherlands.
Kelly J BrunstUniversity of Cincinnati, College of Medicine, Department of Environmental Health, Cincinnati, OH, USA.
Silvia AlemanyISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7925-6767
Nancy S McBrideUniversity of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.
Paul YousefiUniversity of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.ORCID http://orcid.org/0000-0003-3284-3240
Jonathan A HeissIcahn School of Medicine at Mount Sinai, Department of Environmental Medicine and Public Health, New York, NY, USA.
Nia McRaeIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Christian M PageCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Jianping JinWestat, Durham, NC, USA.ORCID http://orcid.org/0000-0002-3774-1609
Giancarlo PesceINSERM UMR-S 1136, EPAR, Saint-Antoine Medical School, Paris, France.ORCID http://orcid.org/0000-0003-4925-6325
Doretta CaramaschiUniversity of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.
Sheryl L Rifas-ShimanHarvard Medical School, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Nastassja KoenUniversity of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa.
Charleen D AdamsBeckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA, USA.
Maria C MagnusUniversity of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.
Nour BaïzINSERM UMR-S 1136, EPAR, Saint-Antoine Medical School, Paris, France.
Andrew RatanatharathornColumbia University, Department of Epidemiology, New York City, NY, USA.ORCID http://orcid.org/0000-0001-9855-0438
Darina CzamaraMax-Planck-Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0001-7381-904X
Siri E HåbergCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Elena ColicinoIcahn School of Medicine at Mount Sinai, Department of Environmental Medicine and Public Health, New York, NY, USA.
Andrea A BaccarelliColumbia University Mailman School of Public Health, Precision Environmental Health Lab, New York, NY, USA.ORCID http://orcid.org/0000-0002-3436-0640
Andres CardenasUniversity of California, Division of Environmental Health Sciences, School of Public Health, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-2284-3298
Dawn L DeMeoBrigham and Women's Hospital, Channing Division of Network Medicine, Boston, MA, USA.
Deborah A LawlorUniversity of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.ORCID http://orcid.org/0000-0002-6793-2262
Caroline L ReltonUniversity of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.
Janine F FelixErasmus MC, University Medical Center Rotterdam, Generation R Study Group, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-9801-5774
Marinus H van IJzendoornErasmus University Rotterdam, Department of Psychology, Education, and Child Studies, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1144-454X
Marian J Bakermans-KranenburgLeiden University, Leiden Institute for Brain and Cognition, Leiden, The Netherlands.
Eero KajantieFinnish Institute for Health and Welfare, Helsinki, Finland.
Katri RäikkönenUniversity of Helsinki, Department of Psychology and Logopedics, Helsinki, Finland.
Jordi SunyerISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Gemma C SharpUniversity of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.ORCID http://orcid.org/0000-0003-2906-4035
Lotte C HoutepenUniversity of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.ORCID http://orcid.org/0000-0003-1442-8852
Ellen A NohrUniversity of Southern Denmark, Institute of Clinical Research and Department of Gynaecology and Obstetrics, Odense, Denmark.
Thorkild I A SørensenUniversity of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.
Martha M Téllez-RojoNational Institute of Public Health, Center for Nutrition and Health Research, Cuernavaca, Mor, Mexico.
Robert O WrightIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Isabella Annesi-MaesanoINSERM UMR-S 1136, EPAR, Saint-Antoine Medical School, Paris, France.ORCID http://orcid.org/0000-0002-6340-9300
John WrightBradford Institute for Health Research, Bradford Teaching Hospitals, NHS Foundation Trust, Bradford, UK.
Marie-France HivertHarvard Medical School, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Rosalind J WrightIcahn School of Medicine at Mount Sinai, Environmental Medicine & Public Health, Institute for Exposomic Research, New York, NY, USA.
Heather J ZarUniversity of Cape Town, Department of Paediatrics and Child Health, Cape Town, South Africa.
Dan J SteinUniversity of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-7218-7810
Stephanie J LondonEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0003-4911-5290
Charlotte A M Cecil *Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, The Netherlands.
Henning Tiemeier *Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, The Netherlands. tiemeier@hsph.harvard.edu.ORCID http://orcid.org/0000-0002-4395-1397
Jari Lahti *University of Helsinki, Department of Psychology and Logopedics, Helsinki, Finland.ORCID http://orcid.org/0000-0002-4310-5297
University of Bristol · GBUniversity of Helsinki · FIIcahn School of Medicine at Mount Sinai · USHarvard University · USInserm · FRSouth African Medical Research Council · ZAErasmus MC · NLLeiden University · NLNorwegian Institute of Public Health · NOUniversitat Pompeu Fabra · ESBradford Teaching Hospitals NHS Foundation Trust · GBBrigham and Women's Hospital · USCity of Hope · USColumbia University · USInstituto Nacional de Salud Pública · MXLeiden University Medical Center · NLMax Planck Institute of Psychiatry · DENational Institutes of Health · USOslo University Hospital · NOUniversity of Cambridge · GB

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Stress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4M
Norway Mother & Child Cohort Study (MoBa) Continued Specimen Collection, and Tools to Enhance Use and CollaborationN01ES75558 · NIEHS · NORWEGIAN INSTITUTE OF PUBLIC HEALTH · PI MAGNUS, PER · 2007 to 2016
$11.8M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Genetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8M
BPA, Phthalates & Stress: Mechanisms and Interactions for Childhood ObesityR01ES021357 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA, WRIGHT, ROBERT O · 2012 to 2016
$3.3M
Metal Mixtures and NeurodevelopmentR01ES014930 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROBERT O · 2006 to 2010
$3.2M
Perinatal Programming of Infant Stress Reactivity and the Atopic PhenotypeR01HL095606 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BOSQUET ENLOW, MICHELLE A, WRIGHT, ROSALIND J · 2010 to 2013
$3.1M
Early Life DNA Methylation and Childhood Allergic DiseaseR01HL111108 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMEO, DAWN L · 2013 to 2016
$3.0M
British Heart Foundation AA/18/7/34219British Heart Foundation CS/16/4/32482British Heart Foundation FS/17/60/33474Department of Health NF-SI-0616-10102Intramural NIH HHS Z01 ES025045Intramural NIH HHS Z01 ES049019Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_12013/2Medical Research Council MR/K021656/1Medical Research Council MR/S009310/1Medical Research Council MR/S036520/1NHLBI NIH HHS R01 HL095606NHLBI NIH HHS R01 HL111108NHLBI NIH HHS R01 HL114396NICHD NIH HHS R01 HD034568NICHD NIH HHS R01 HD068437NICHD NIH HHS R21 HD085849NIEHS NIH HHS N01ES75558NIEHS NIH HHS P30 ES006096NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R00 ES024116NIEHS NIH HHS R01 ES013744NIEHS NIH HHS R01 ES014930NIEHS NIH HHS R01 ES021357NIH HHS UH3 OD023286NINDS NIH HHS U01 NS047537NINR NIH HHS R01 NR013945Wellcome Trust 084762MAWellcome Trust 217065/Z/19/ZWellcome Trust WT101597MA
6 · The paper itself

Abstract

Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations between maternal anxiety, measured prospectively during pregnancy, and genome-wide DNAm from umbilical cord blood. Sixteen non-overlapping cohorts from 12 independent longitudinal studies of the Pregnancy And Childhood Epigenetics Consortium participated, resulting in a combined dataset of 7243 mother-child dyads. We examined prenatal anxiety in relation to genome-wide DNAm and differentially methylated regions. We observed no association between the general symptoms of anxiety during pregnancy or pregnancy-related anxiety, and DNAm at any of the CpG sites, after multiple-testing correction. Furthermore, we identify no differentially methylated regions associated with maternal anxiety. At the cohort-level, of the 21 associations observed in individual cohorts, none replicated consistently in the other cohorts. In conclusion, contrary to some previous studies proposing cord blood DNAm as a promising potential mechanism explaining the link between maternal anxiety during pregnancy and adverse outcomes in offspring, we found no consistent evidence for any robust associations between maternal anxiety and DNAm in cord blood. Larger studies and analysis of DNAm in other tissues may be needed to establish subtle or subgroup-specific associations between maternal anxiety and the foetal epigenome.

Indexed as

DNA MethylationEpigenomeAnxietyEpigenesis, GeneticEpigenomicsFemaleHumansPregnancy

Identifiers

PMID33414500
PMCPMC8595870
OpenAlexW3119080730

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.